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Summary

Linsley, S., Brady, W., Urnes, M., Grosmaire, L. S., Damle, N. K., & Ledbetter, J. A. (2013)

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.

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Evidence for an additional ligand, distinct from B7, for the CTLA-4 receptor.

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B70 antigen is a second ligand for CTLA-4 and CD28

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Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1.

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