The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Preferential Migration of Activated CD4 + and CD8 + T Cells in Response to MIP-1α and MIP-1β
Abstract
Recombinant human macrophage inflammatory protein-1α (rhMIP-1α) and rhMIP-1β were potent chemoattractants of human T lymphocytes. These rhMIP-1 cytokines attracted only T cells activated by monoclonal antibody to CD3 and did not attract unstimulated lymphocytes. Phenotypic analysis revealed that CD4 + T cells were capable of migrating in response to rhMIP-1β, whereas rhMIP-1α induced chemotaxis of predominantly CD8 + T lymphocytes. Activated naive and memory T cells also migrated in response to rhMIP-1 cytokines. Furthermore, these cytokines enhanced the ability of T cells to bind to an endothelial cell monolayer. These results suggest that rhMIP-1 cytokines preferentially recruit specific T cell subsets during the evolution of the immune response.
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Metadata
- Authors
- Taub, D. D., Conlon, K., Lloyd, A. R., Oppenheim, J. J., & Kelvin, D. J.
- Venue
- Science
- Published
- 1993-04-16
- Volume
- 260
- Issue
- 5106
- Pages
- 355-358
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984123968
- Cited by
- 730
- References
- 1
- FWCI
- 24.38
- Type
- journal article
- Language
- en
- Open access
- closed
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