The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Binding of L-Selectin to the Vascular Sialomucin CD34
Abstract
The adhesive interactions between leukocyte L-selectin and the endothelium are involved in the migration of lymphocytes through peripheral lymph nodes and of neutrophils to sites of inflammation. A recombinant L-selectin stains high endothelial venules (HEVs) in lymph nodes and recognizes sulfated carbohydrates found on two endothelial glycoproteins, Sgp50 and Sgp90. Amino acid sequencing of purified Sgp90 revealed a protein core identical to that of CD34, a sialomucin expressed on hematopoietic stem cells and endothelium. A polyclonal antiserum to recombinant murine CD34 stains peripheral lymph node endothelium and recognizes Sgp90 that is functionally bound by L-selectin. Thus, an HEV glycoform of CD34 can function as a ligand for L-selectin.
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Citations
Cites
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Spertini, O., Luscinskas, F. W., Kansas, G. S., Munro, J. M., Griffin, J. D., Gimbrone, M. A., & Tedder, T. F. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.8.2565 · Cited by 394
Cited by
Varki, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7390 · Cited by 946
Mechanisms That Regulate the Function of the Selectins and Their Ligands
VESTWEBER, D., & BLANKS, J. E. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.181 · Cited by 932
P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin.
Moore, K. L., Patel, K. D., Bruehl, R. E., Li, F., Johnson, D. A., Lichenstein, H. S., Cummings, R. D., Bainton, D. F., & McEver, R. P. (1995) · The Journal of cell biology · doi:10.1083/jcb.128.4.661 · Cited by 710
L-selectin-mediated lymphocyte rolling on MAdCAM-1
Berg, E. L., McEvoy, L. M., Berlin, C., Bargatze, R. F., & Butcher, E. C. (1993) · Nature · doi:10.1038/366695a0 · Cited by 536
Leukocyte Trafficking Mediated by Selectin-Carbohydrate Interactions
McEver, R. P., Moore, K. L., & Cummings, R. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.19.11025 · Cited by 512
Metadata
- Authors
- Baumheter, S., Singer, M. S., Henzel, W., Hemmerich, S., Renz, M., Rosen, S. D., & Lasky, L. A.
- Venue
- Science
- Published
- 1993-10-15
- Volume
- 262
- Issue
- 5132
- Pages
- 436-438
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2080780289
- Cited by
- 619
- References
- 2
- FWCI
- 22.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Baumheter, S., Singer, M. S., Henzel, W., Hemmerich, S., Renz, M., Rosen, S. D., & Lasky, L. A. (1993). Binding of L-Selectin to the Vascular Sialomucin CD34. Science. https://doi.org/10.1126/science.7692600
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