Cloning of Immunoglobulin-Superfamily Members Associated with HLA-C and HLA-B Recognition by Human Natural Killer Cells
Abstract
Cytotoxicity by natural killer (NK) cells is inhibited by major histocompatibility complex (MHC) class I molecules on target cells. This inhibition may be mediated by NK receptors with different MHC specificities. A family of four NK-specific complementary DNAs (cDNAs), designated NKATs (NK-associated transcripts), was identified that encoded related transmembrane proteins, characterized by an extracellular region with two or three immunoglobulin-superfamily domains and by a cytoplasmic domain with an unusual antigen receptor activation motif (ARAM). The distribution of these cDNAs was clonotypic and correlated with NK cell inhibition by particular class I alleles. Thus, NKAT cDNAs may encode receptors for class I molecules on NK cells.
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Many of the downregulated proteins in TET2-CH are markers of other haematopoietic lineages, such as KIR2DL2 and KIR2DL3, and PRG2 and PRG3.
“Many of the downregulated proteins are markers of other haematopoietic lineages, such as KIR2DL2 and KIR2DL3 (natural killer cell activation)52, and PRG2 and PRG3 (constituents of eosinophil granules also involved in basophil stimulation)53,54.”
From Rare variant associations with plasma protein levels in the UK Biobank (2023) · cites this paper as [52]
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- Authors
- Colonna, M., & Samaridis, J.
- Affiliations
- University of Basel (CH)
- ORCID
- Colonna, Marco
- Venue
- Science
- Published
- 1995-04-21
- Volume
- 268
- Issue
- 5209
- Pages
- 405-408
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079786360
- Cited by
- 736
- References
- 0
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 8 · 2023: 5 · 2022: 10 · 2021: 8 · 2020: 11 · 2019: 12 · 2018: 6 · 2017: 17 · 2016: 12 · 2015: 22 · 2014: 15 · 2013: 21 · 2012: 11
- FWCI
- 28.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- natural killer cells, immunoglobulin superfamily, HLA-C, HLA-B, MHC class I recognition, NK cell inhibition, transmembrane receptors, NK cell receptors, cDNA cloning
- MeSH terms
- Amino Acid Sequence, Animals, Antigens, Ly, Base Sequence, Cell Line, Cloning, Molecular, Humans, Killer Cells, Natural, Membrane Glycoproteins, Molecular Sequence Data, Receptors, Immunologic, Blotting, Southern, HLA-B Antigens, HLA-C Antigens, Sequence Alignment, DNA, Complementary, Lectins, C-Type, Receptors, KIR, Receptors, KIR2DL1, Receptors, KIR3DS1, Receptors, NK Cell Lectin-Like
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