The DOI matches its Crossref record.
KAI1 , a Metastasis Suppressor Gene for Prostate Cancer on Human Chromosome 11p11.2
Abstract
A gene from human chromosome 11p11.2 was isolated and was shown to suppress metastasis when introduced into rat AT6.1 prostate cancer cells. Expression of this gene, designated KAI1 , was reduced in human cell lines derived from metastatic prostate tumors. KAI1 specifies a protein of 267 amino acids, with four hydrophobic and presumably transmembrane domains and one large extracellular hydrophilic domain with three potential N-glycosylation sites. KAI1 is evolutionarily conserved, is expressed in many human tissues, and encodes a member of a structurally distinct family of leukocyte surface glycoproteins. Decreased expression of this gene may be involved in the malignant progression of prostate and other cancers.
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Citations
Cited by
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Nishida-Aoki, N., Tominaga, N., Takeshita, F., Sonoda, H., Yoshioka, Y., & Ochiya, T. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.10.009 · Cited by 208
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Metadata
- Authors
- Dong, J.-T., Lamb, P. W., Rinker-Schaeffer, C. W., Vukanovic, J., Ichikawa, T., Isaacs, J. T., & Barrett, J. C.
- Venue
- Science
- Published
- 1995-05-12
- Volume
- 268
- Issue
- 5212
- Pages
- 884-886
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2017767253
- Cited by
- 757
- References
- 0
- FWCI
- 16.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: KAI1 , a Metastasis Suppressor Gene for Prostate Cancer on Human Chromosome 11p11.2. https://app.cochat.ai/papers/10.1126/science.7754374
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- Dong, J.-T., Lamb, P. W., Rinker-Schaeffer, C. W., Vukanovic, J., Ichikawa, T., Isaacs, J. T., & Barrett, J. C. (1995). KAI1 , a Metastasis Suppressor Gene for Prostate Cancer on Human Chromosome 11p11.2. Science. https://doi.org/10.1126/science.7754374
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
