The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms
Abstract
Mammalian mitogen-activated protein (MAP) kinases include extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK), and p38 subgroups. These MAP kinase isoforms are activated by dual phosphorylation on threonine and tyrosine. Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. These MKK isoforms did not activate the ERK subgroup of MAP kinases, but MKK4 did activate JNK. These data demonstrate that the activators of p38 (MKK3 and MKK4), JNK (MKK4), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.
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“a peptide derived from MKK4 (pepMKK4) bound to JNK1 and p38α with similar affinities, as expected.”
From Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove (2012) · cites this paper as [23]
Citations
Cites
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Self-citationA MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
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Self-citationThe stress-activated protein kinase subfamily of c-Jun kinases
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Self-citationAn Osmosensing Signal Transduction Pathway in Yeast
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Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273
Self-citationMitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
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Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
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“MKK3 and MKK6 are thought to be the major protein kinases responsible for p38 activation (89, 143, 344), but MKK4 has also been shown to possess some activity toward p38 (233).”
Background
Metadata
- Authors
- Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Venue
- Science
- Published
- 1995-02-03
- Volume
- 267
- Issue
- 5198
- Pages
- 682-685
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1998487776
- Cited by
- 1,555
- References
- 29
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 9 · 2023: 12 · 2022: 16 · 2021: 19 · 2020: 14 · 2019: 20 · 2018: 16 · 2017: 19 · 2016: 24 · 2015: 15 · 2014: 27 · 2013: 25 · 2012: 27
- FWCI
- 53.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca058396-09)
- National Cancer Institute (CA 58396)
- National Institute of General Medical Sciences (GM 37696, P01GM037696)
- National Institute of Allergy and Infectious Diseases (AI 15136, R01AI015136)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- MAPK signaling, MKK3, MKK4, p38 MAPK, ERK, JNK, signaling pathways, dual phosphorylation
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Cell Line, Cloning, Molecular, Enzyme Activation, Humans, Molecular Sequence Data, Phosphorylation, Protein-Tyrosine Kinases, Substrate Specificity, Transfection, Signal Transduction, Protein Serine-Threonine Kinases, Calcium-Calmodulin-Dependent Protein Kinases, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase Kinases, JNK Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, MAP Kinase Kinase 3, MAP Kinase Kinase 4
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