Han, Jiahuai

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

He, W.-T., Wan, H., Hu, L., Chen, P., Wang, X., Huang, Z., Yang, Z.-H., Zhong, C.-Q., & Han, J. (2015) · Cell Research

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 2,517

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

Zhang, D.-W., Shao, J., Lin, J., Zhang, N., Lu, B.-J., Lin, S.-C., Dong, M.-Q., & Han, J. (2009) · Science

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 1,931

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 1,555

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

Chen, X., He, W.-T., Hu, L., Li, J., Fang, Y., Wang, X., Xu, X., Wang, Z., Huang, K., & Han, J. (2016) · Cell Research

Inflammasome and immune disordersCell death mechanisms and regulation

Cited by 831

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

Lin, S.-Y., Li, T. Y., Liu, Q., Zhang, C., Li, X., Chen, Y., Zhang, S.-M., Lian, G., Liu, Q., Ruan, K., et al. (2012) · Science

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 365

PRAK Is Essential for ras-Induced Senescence and Tumor Suppression

Sun, P., Yoshizuka, N., New, L., Moser, B. A., Li, Y., Liao, R., Xie, C., Chen, J., Deng, Q., Yamout, M., et al. (2007) · Cell

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 321

Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis

Wu, X.-N., Yang, Z.-H., Wang, X.-K., Zhang, Y., Wan, H., Song, Y., Chen, X., Shao, J., & Han, J. (2014) · Cell Death & Differentiation

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 299

HDAC4, a Human Histone Deacetylase Related to Yeast HDA1, Is a Transcriptional Corepressor

Wang, A. H., Bertos, N. R., Vezmar, M., Pelletier, N., Crosato, M., Heng, H. H., Th’ng, J., Han, J., & Yang, X.-J. (1999) · Molecular and Cellular Biology

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 294

The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution

Wang, Z., Harkins, P. C., Ulevitch, R. J., Han, J., Cobb, M. H., & Goldsmith, E. J. (1997) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 275

MAPK signaling in inflammation-associated cancer development

Huang, P., Han, J., & Hui, L. (2010) · Protein & Cell

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 273

Kinases mst1 and mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

Geng, J., Sun, X., Wang, P., Zhang, S., Wang, X., Wu, H., Hong, L., Xie, C., Li, X., Zhao, H., et al. (2015) · Nature Immunology

Neutrophil, Myeloperoxidase and Oxidative MechanismsImmune Response and Inflammation

Cited by 264

MicroRNAs and cardiovascular diseases

Ono, K., Kuwabara, Y., & Han, J. (2011) · The FEBS Journal

MicroRNA in disease regulationCongenital heart defects research

Cited by 169

Ppm1b negatively regulates necroptosis through dephosphorylating Rip3

Chen, W., Wu, J., Li, L., Zhang, Z., Ren, J., Liang, Y., Chen, F., Yang, C., Zhou, Z., Sean Su, S., et al. (2015) · Nature Cell Biology

Cell death mechanisms and regulationProtein Tyrosine Phosphatases

Cited by 161

Calcineurin Negatively Regulates TLR-Mediated Activation Pathways

Kang, Y. J., Kusler, B., Otsuka, M., Hughes, M., Suzuki, N., Suzuki, S., Yeh, W.-C., Akira, S., Han, J., & Jones, P. P. (2007) · The Journal of Immunology

Immune Response and InflammationSignaling Pathways in Disease

Cited by 104

2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter

Yang, Z., Jiang, B., Wang, Y., Ni, H., Zhang, J., Xia, J., Shi, M., Hung, L.-M., Ruan, J., Mak, T. W., et al. (2017) · Cell Reports

Epigenetics and DNA MethylationGlioma Diagnosis and Treatment

Cited by 78