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Selfish Behavior of Restriction-Modification Systems
Abstract
Plasmids carrying gene pairs encoding type II DNA restriction endonucleases and their cognate modification enzymes were shown to have increased stability in Escherichia coli . The descendants of cells that had lost these genes appeared unable to modify a sufficient number of recognition sites in their chromosomes to protect them from lethal attack by the remaining restriction enzyme molecules. The capacity of these genes to act as a selfish symbiont is likely to have contributed to the evolution of restriction-modification gene pairs.
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Citations
Cited by
Horizontal gene transfer in prokaryotes: Quantification and classification
Koonin, E. V., Makarova, K. S., & Aravind, L. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.709 · Cited by 1,126
The phage‐host arms race: Shaping the evolution of microbes
Stern, A., & Sorek, R. (2011) · BioEssays · doi:10.1002/bies.201000071 · Cited by 527
Kobayashi, I. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.18.3742 · Cited by 513
Self-citationType I Restriction Systems: Sophisticated Molecular Machines (a Legacy of Bertani and Weigle)
Murray, N. E. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.2.412-434.2000 · Cited by 455
When Less Is More: Gene Loss as an Engine of Evolutionary Change
Olson, M. V. (1999) · The American Journal of Human Genetics · doi:10.1086/302219 · Cited by 437
Metadata
- Authors
- Naito, T., Kusano, K., & Kobayashi, I.
- Venue
- Science
- Published
- 1995-02-10
- Volume
- 267
- Issue
- 5199
- Pages
- 897-899
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079726617
- Cited by
- 367
- References
- 0
- FWCI
- 9.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Selfish Behavior of Restriction-Modification Systems. https://app.cochat.ai/papers/10.1126/science.7846533
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- Naito, T., Kusano, K., & Kobayashi, I. (1995). Selfish Behavior of Restriction-Modification Systems. Science. https://doi.org/10.1126/science.7846533
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
