The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Modulation of Serotonin-Controlled Behaviors by G o in Caenorhabditis elegans
Abstract
Seven transmembrane receptors and their associated heterotrimeric guanine nucleotide-binding proteins (G proteins) have been proposed to play a key role in modulating the activities of neurons and muscles. The physiological function of the Caenorhabditis elegans G protein G o has been genetically characterized. Mutations in the goa-1 gene, which encodes an α subunit of G o (Gα o ), cause behavioral defects similar to those observed in mutants that lack the neurotransmitter serotonin (5-HT), and goa-1 mutants are partially resistant to exogenous 5-HT. Mutant animals that lack Gα o and transgenic animals that overexpress Gα o [ goa-1 ( xs ) animals] have reciprocal defects in locomotion, feeding, and egg laying behaviors. In normal animals, all of these behaviors are regulated by 5-HT. These results demonstrate that the level of G o activity is a critical determinant of several C. elegans behaviors and suggest that G o mediates many of the behavioral effects of 5-HT.
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Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
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The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits
Tang, W.-J., & Gilman, A. G. (1991) · Science · doi:10.1126/science.1962211 · Cited by 1,091
The pharynx of Caenorhabditis elegans
Albertson, D. G., & Thompson, J. N. (1976) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1976.0085 · Cited by 649
Cited by
Ross, E. M., & Wilkie, T. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.795 · Cited by 1,156
Sawin, E. R., Ranganathan, R., & Horvitz, H. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)81199-x · Cited by 1,076
Slack, F. J., Basson, M., Liu, Z., Ambros, V., Horvitz, H. R., & Ruvkun, G. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80245-2 · Cited by 751
Lethargus is a Caenorhabditis elegans sleep-like state
Raizen, D. M., Zimmerman, J. E., Maycock, M. H., Ta, U. D., You, Y.-J., Sundaram, M. V., & Pack, A. I. (2008) · Nature · doi:10.1038/nature06535 · Cited by 536
A Central Role of the BK Potassium Channel in Behavioral Responses to Ethanol in C. elegans
Davies, A. G., Pierce-Shimomura, J. T., Kim, H., VanHoven, M. K., Thiele, T. R., Bonci, A., Bargmann, C. I., & McIntire, S. L. (2003) · Cell · doi:10.1016/s0092-8674(03)00979-6 · Cited by 357
Metadata
- Authors
- Ségalat, L., Elkes, D. A., & Kaplan, J. M.
- Venue
- Science
- Published
- 1995-03-17
- Volume
- 267
- Issue
- 5204
- Pages
- 1648-1651
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993678582
- Cited by
- 308
- References
- 4
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
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