The DOI matches its Crossref record.
Skeletal Repair by in Situ Formation of the Mineral Phase of Bone
Abstract
A process has been developed for the in situ formation of the mineral phase of bone. Inorganic calcium and phosphate sources are combined to form a paste that is surgically implanted by injection. Under physiological conditions, the material hardens in minutes concurrent with the formation of dahllite. After 12 hours, dahllite formation was nearly complete, and an ultimate compressive strength of 55 megapascals was achieved. The composition and crystal morphology of the dahllite formed are similar to those of bone. Animal studies provide evidence that the material is remodeled in vivo. A novel approach to skeletal repair is being tested in human trials for various applications; in one of the trials the new biomaterial is being percutaneously placed into acute fractures. After hardening, it serves as internal fixation to maintain proper alignment while healing occurs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Injectable biodegradable materials for orthopedic tissue engineering
Temenoff, J. S., & Mikos, A. G. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00108-3 · Cited by 554
Calcium orthophosphate cements for biomedical application
Dorozhkin, S. V. (2008) · Journal of Materials Science · doi:10.1007/s10853-008-2527-z · Cited by 334
Reaction Behavior of Biodegradable, Photo-Cross-Linkable Polyanhydrides
Muggli, D. S., Burkoth, A. K., Keyser, S. A., Lee, H. R., & Anseth, K. S. (1998) · Macromolecules · doi:10.1021/ma980108n · Cited by 107
Metadata
- Authors
- Constantz, B. R., Ison, I. C., Fulmer, M. T., Poser, R. D., Smith, S. T., VanWagoner, M., Ross, J., Goldstein, S. A., Jupiter, J. B., & Rosenthal, D. I.
- Venue
- Science
- Published
- 1995-03-24
- Volume
- 267
- Issue
- 5205
- Pages
- 1796-1799
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2095172141
- Cited by
- 728
- References
- 0
- FWCI
- 26.19
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Skeletal Repair by in Situ Formation of the Mineral Phase of Bone. https://app.cochat.ai/papers/10.1126/science.7892603
- The paper
- Constantz, B. R., Ison, I. C., Fulmer, M. T., Poser, R. D., Smith, S. T., VanWagoner, M., Ross, J., Goldstein, S. A., Jupiter, J. B., & Rosenthal, D. I. (1995). Skeletal Repair by in Situ Formation of the Mineral Phase of Bone. Science. https://doi.org/10.1126/science.7892603
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
