The DOI matches its Crossref record.
The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major
Abstract
Protection induced by vaccination depends on the capacity of the vaccine to elicit an appropriate immune response. In leishmaniasis, protection requires leishmanial-specific CD4 + T helper (T H ) cells. Vaccination of BALB/c mice with leishmanial antigens and interleukin-12 (IL-12) promoted the development of leishmanial-specific CD4 + T H 1 cells. These mice were resistant to subsequent infection with Leishmania major . Thus, IL-12 is an effective adjuvant for the initiation of protective cell-mediated immunity against leishmaniasis and may be an important component in other vaccines that need to induce cell-mediated immunity.
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Cited by
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Trembleau, S., Penna, G., Bosi, E., Mortara, A., Gately, M. K., & Adorini, L. (1995) · The Journal of experimental medicine · doi:10.1084/jem.181.2.817 · Cited by 423
Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1
Taki, S., Sato, T., Ogasawara, K., Fukuda, T., Sato, M., Hida, S., Suzuki, G., Mitsuyama, M., Shin, E.-H., Kojima, S., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80443-4 · Cited by 353
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Metadata
- Authors
- Afonso, L. C. C., Scharton, T. M., Vieira, L. Q., Wysocka, M., Trinchieri, G., & Scott, P.
- Venue
- Science
- Published
- 1994-01-14
- Volume
- 263
- Issue
- 5144
- Pages
- 235-237
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061517625
- Cited by
- 680
- References
- 0
- FWCI
- 102.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Afonso, L. C. C., Scharton, T. M., Vieira, L. Q., Wysocka, M., Trinchieri, G., & Scott, P. (1994). The Adjuvant Effect of Interleukin-12 in a Vaccine Against Leishmania major. Science. https://doi.org/10.1126/science.7904381
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
