The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.
Open accessAbstract
T cells play a major role in the development of insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice. Administration of interleukin 12 (IL-12), a key cytokine which guides the development of T helper type 1 (Th1) CD4+ T cells, induces rapid onset of IDDM in NOD, but not in BALB/c mice. Histologically, IL-12 administration induces massive infiltration of lymphoid cells, mostly T cells, in the pancreatic islets of NOD mice. CD4+ pancreas-infiltrating T cells, after activation by insolubilized anti T cell receptor antibody, secrete high levels of interferon gamma and low levels of IL-4. Therefore, IL-12 administration accelerates IDDM development in genetically susceptible NOD mice, and this correlates with increased Th1 cytokine production by islet-infiltrating cells. These results hold implications for the pathogenesis, and possibly for the therapy of IDDM and of other Th1 cell-mediated autoimmune diseases.
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Cites
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Cited by
THE NOD MOUSE: A Model of Immune Dysregulation
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Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
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β cell apoptosis in T cell-mediated autoimmune diabetes
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Metadata
- Authors
- Trembleau, S., Penna, G., Bosi, E., Mortara, A., Gately, M. K., & Adorini, L.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1995-02-01
- Volume
- 181
- Issue
- 2
- Pages
- 817-821
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2133604102
- Cited by
- 423
- References
- 26
- FWCI
- 21.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Trembleau, S., Penna, G., Bosi, E., Mortara, A., Gately, M. K., & Adorini, L. (1995). Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. The Journal of experimental medicine. https://doi.org/10.1084/jem.181.2.817
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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