Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1
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Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice lacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiation is found to be associated with defects in multiple cell types, namely impaired production of interleukin-12 by macrophages, hyporesponsiveness of CD4+ T cells to interleukin-12, and defective development of natural killer cells. These results indicate the involvement of IRF-1 in multiple stages of the Th1 limb of the immune response.
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ICSBP alone is able to activate mouse and human IL-12 p40 promoters, acting through the Ets site, and exogenous IRF-1 synergizes with ICSBP.
“It was shown that ICSBP alone is able to activate mouse and human IL-12 p40 promoters.”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [45]
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- Authors
- Taki, S., Sato, T., Ogasawara, K., Fukuda, T., Sato, M., Hida, S., Suzuki, G., Mitsuyama, M., Shin, E.-H., Kojima, S., Taniguchi, T., & Asano, Y.
- Affiliations
- The University of Tokyo (JP)
- National Institute of Radiological Sciences (JP)
- Niigata University (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Corresponding author
- Taniguchi, Tadatsugu
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 1997-06
- Volume
- 6
- Issue
- 6
- Pages
- 673-679
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1977795184
- Cited by
- 353
- References
- 58
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 12 · 2013: 10 · 2012: 13
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- IRF1, Th1 response, Th1/Th2 differentiation, T helper cell differentiation, IL-12, macrophages, CD4+ T cells, natural killer cell development, transcription factors
- MeSH terms
- Animals, Antigen-Presenting Cells, Cell Differentiation, DNA-Binding Proteins, Gene Expression Regulation, Killer Cells, Natural, Phosphoproteins, Transcription Factors, CD4-Positive T-Lymphocytes, Mice, Knockout, Th1 Cells, Th2 Cells, Interleukin-12, Interferon Regulatory Factor-1, Mice
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