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G h : a GTP-Binding Protein with Transglutaminase Activity and Receptor Signaling Function
Abstract
The α 1 -adrenergic receptors activate a phospholipase C enzyme by coupling to members of the large molecular size (approximately 74 to 80 kilodaltons) Gα h family of guanosine triphosphate (GTP)-binding proteins. Rat liver Gα h is now shown to be a tissue transglutaminase type II (TGase II). The transglutaminase activity of rat liver TGase II expressed in COS-1 cells was inhibited by the nonhydrolyzable GTP analog guanosine 5′- O -(3-thiotriphosphate) or by α 1 -adrenergic receptor activation. Rat liver TGase II also mediated α 1 -adrenergic receptor stimulation of phospholipase C activity. Thus, Gα h represents a new class of GTP-binding proteins that participate in receptor signaling and may be a component of a complex regulatory network in which receptor-stimulated GTP binding switches the function of Gα h from transglutamination to receptor signaling.
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Citations
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Metadata
- Authors
- Nakaoka, H., Perez, D. M., Baek, K. J., Das, T., Husain, A., Misono, K., Im, M.-J., & Graham, R. M.
- Venue
- Science
- Published
- 1994-06-10
- Volume
- 264
- Issue
- 5165
- Pages
- 1593-1596
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061413318
- Cited by
- 547
- References
- 0
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nakaoka, H., Perez, D. M., Baek, K. J., Das, T., Husain, A., Misono, K., Im, M.-J., & Graham, R. M. (1994). G h : a GTP-Binding Protein with Transglutaminase Activity and Receptor Signaling Function. Science. https://doi.org/10.1126/science.7911253
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