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GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle
Abstract
For survival, embryonic motoneurons in vertebrates depend on as yet undefined neurotrophic factors present in the limb bud. Members of the neurotrophin family are currently the best candidates for such neurotrophic factors, but inactivation of their receptor genes leads to only partial loss of motoneurons, which suggests that other factors are involved. Glial cell line-derived neurotrophic factor (GDNF), originally identified as a trophic factor specific for dopaminergic neurons, was found to be 75-fold more potent than the neurotrophins in supporting the survival of purified embryonic rat motoneurons in culture. GDNF messenger RNA was found in the immediate vicinity of motoneurons during the period of cell death in development. In vivo, GDNF rescues and prevents the atrophy of facial motoneurons that have been deprived of target-derived survival factors by axotomy. GDNF may therefore be a physiological trophic factor for spinal motoneurons. Its potency and specificity in vitro and in vivo also make it a good candidate for treatment of motoneuron disease.
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Cited by
Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
Tomac, A., Lindqvist, E., Lin, L.-F. H., Ögren, S. O., Young, D., Hoffer, B. J., & Olson, L. (1995) · Nature · doi:10.1038/373335a0 · Cited by 1,079
Neurturin, a relative of glial-cell-line-derived neurotrophic factor
Kotzbauer, P. T., Lampe, P. A., Heuckeroth, R. O., Golden, J. P., Creedon, D. J., Johnson Jr, E. M., & Milbrandt, J. (1996) · Nature · doi:10.1038/384467a0 · Cited by 710
Neurotrophic factors and their receptors.
Barbacid, M. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80022-0 · Cited by 577
The Germline Stem Cell Niche Unit in Mammalian Testes
Oatley, J. M., & Brinster, R. L. (2012) · Physiological Reviews · doi:10.1152/physrev.00025.2011 · Cited by 513
Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons
Horger, B. A., Nishimura, M. C., Armanini, M. P., Wang, L.-C., Poulsen, K. T., Rosenblad, C., Kirik, D., Moffat, B., Simmons, L., Johnson, E., et al. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-13-04929.1998 · Cited by 338
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Metadata
- Authors
- Henderson, C. E., Phillips, H. S., Pollock, R. A., Davies, A. M., Lemeulle, C., Armanini, M., Simmons, L., Moffet, B., Vandlen, R. A., Koliatsos, V. E., & Rosenthal, A.
- Venue
- Science
- Published
- 1994-11-11
- Volume
- 266
- Issue
- 5187
- Pages
- 1062-1064
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994452959
- Cited by
- 1,272
- References
- 0
- FWCI
- 21.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Henderson, C. E., Phillips, H. S., Pollock, R. A., Davies, A. M., Lemeulle, C., Armanini, M., Simmons, L., Moffet, B., Vandlen, R. A., Koliatsos, V. E., & Rosenthal, A. (1994). GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle. Science. https://doi.org/10.1126/science.7973664
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