Neurotrophic factors and their receptors.

Barbacid, Mariano

doi:10.1016/0955-0674(95)80022-0

Cited by 577Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal Signaling

Neurotrophic factors and their receptors.

Barbacid, Mariano·1995·Current Opinion in Cell Biology

DOI 10.1016/0955-0674(95)80022-0

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Abstract

Several new members of the nerve growth factor family of neurotrophins, which comprises nerve growth factor itself, brain-derived neurotrophic factor and neurotrophins-3, -4 (also known as neurotrophin-5) and -6, have been isolated in recent years. Their signaling receptors have been identified as the Trk family of tyrosine protein kinases, thus facilitating the dissection of the signaling pathways responsible for mediating their trophic properties. More recently, the advent of gene targeting has made it possible to generate strains of mice lacking neurotrophins and their receptors. Analysis of the phenotypes of these mutant animals has provided detailed information on the role that neurotrophins and their receptors play in the ontogeny of the mammalian nervous system.

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Neurotrophins are important to the development and maintenance of functioning neural cells in the brain.
“Neurotrophins are important to the development and maintenance of functioning neural cells in the brain (Barbacid, 1995) and are likely to play a crucial role in mediating the impact of AE on hippocampal neuroplasticity and functioning (Cotman et al., 2007; Voss et al., 2013a; Bolijn and Lucassen, 2015).”
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Authors: Barbacid, M.
Affiliations: Bristol-Myers Squibb (United States) (US)
Corresponding author: Barbacid, Mariano
ORCID: Barbacid, Mariano
Venue: Current Opinion in Cell Biology
Publisher: Elsevier BV
Published: 1995-01
Volume: 7
Issue: 2
Pages: 148-155
ISSN: 0955-0674 (ISSN-L)
DOI: 10.1016/0955-0674(95)80022-0
OpenAlex: W2114216374
Cited by: 577
References: 60
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 8 · 2022: 9 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 11 · 2014: 12 · 2013: 15 · 2012: 14
FWCI: 4.12
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords: neurotrophic factors, neurotrophins, nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, neurotrophin-4, neurotrophin-5, neurotrophin-6, Trk receptors, tyrosine kinase, neurotrophin signaling, gene targeting, knockout mice, brain development
MeSH terms: Animals, Nerve Growth Factors, Signal Transduction, Receptors, Nerve Growth Factor, Receptors, Tumor Necrosis Factor, Receptor Protein-Tyrosine Kinases

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Neurotrophic factors and their receptors.

Abstract

Integrity signals

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