The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Autoproteolysis in hedgehog protein biogenesis
Abstract
Extracellular signaling proteins encoded by the hedgehog (hh) multigene family are responsible for the patterning of a variety of embryonic structures in vertebrates and invertebrates. The Drosophila hh gene has now been shown to generate two predominant protein species that are derived by an internal autoproteolytic cleavage of a larger precursor. Mutations that reduced the efficiency of autoproteolysis in vitro diminished precursor cleavage in vivo and also impaired the signaling and patterning activities of the HH protein. The two HH protein species exhibited distinctive biochemical properties and tissue distribution, and these differences suggest a mechanism that could account for the long- and short-range signaling activities of HH in vivo.
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Citations
Cites
Lee, J. J., von Kessler, D. P., Parks, S., & Beachy, P. A. (1992) · Cell · doi:10.1016/0092-8674(92)90264-d · Cited by 581
Self-citation
Cited by
Hedgehog: functions and mechanisms
Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
Cooper, M. K., Porter, J. A., Young, K. E., & Beachy, P. A. (1998) · Science · doi:10.1126/science.280.5369.1603 · Cited by 848
Self-citationDessaud, E., McMahon, A. P., & Briscoe, J. (2008) · Development · doi:10.1242/dev.009324 · Cited by 734
Mechanisms and functions of Hedgehog signalling across the metazoa
Ingham, P. W., Nakano, Y., & Seger, C. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2984 · Cited by 605
Molecular Models for Vertebrate Limb Development
Johnson, R. L., & Tabin, C. J. (1997) · Cell · doi:10.1016/s0092-8674(00)80364-5 · Cited by 580
Metadata
- Authors
- Lee, J., Ekker, S., von Kessler, D., Porter, J., Sun, B., & Beachy, P.
- Venue
- Science
- Published
- 1994-12-02
- Volume
- 266
- Issue
- 5190
- Pages
- 1528-1537
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026550373
- Cited by
- 547
- References
- 1
- FWCI
- 11.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, J., Ekker, S., von Kessler, D., Porter, J., Sun, B., & Beachy, P. (1994). Autoproteolysis in hedgehog protein biogenesis. Science. https://doi.org/10.1126/science.7985023
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
