The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Potential Role of Human Cytomegalovirus and p53 Interaction in Coronary Restenosis
Abstract
A subset of patients who have undergone coronary angioplasty develop restenosis, a vessel renarrowing characterized by excessive proliferation of smooth muscle cells (SMCs). Of 60 human restenosis lesions examined, 23 (38 percent) were found to have accumulated high amounts of the tumor suppressor protein p53, and this correlated with the presence of human cytomegalovirus (HCMV) in the lesions. SMCs grown from the lesions expressed HCMV protein IE84 and high amounts of p53. HCMV infection of cultured SMCs enhanced p53 accumulation, which correlated temporally with IE84 expression. IE84 also bound to p53 and abolished its ability to transcriptionally activate a reporter gene. Thus, HCMV, and IE84-mediated inhibition of p53 function, may contribute to the development of restenosis.
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Cites
Amplification of a gene encoding a p53-associated protein in human sarcomas
Oliner, J. D., Kinzler, K. W., Meltzer, P. S., George, D. L., & Vogelstein, B. (1992) · Nature · doi:10.1038/358080a0 · Cited by 1,949
Cited by
The Story of Human Cytomegalovirus and Cancer: Increasing Evidence and Open Questions
Michaelis, M., Doerr, H. W., & Cinatl, J. (2009) · Neoplasia · doi:10.1593/neo.81178 · Cited by 293
Cytoplasmic Sequestration of Wild-Type p53 Protein Impairs the G 1 Checkpoint after DNA Damage
Moll, U. M., Ostermeyer, A. G., Haladay, R., Winkfield, B., Frazier, M., & Zambetti, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1126 · Cited by 277
Integrin αvβ3 is a coreceptor for human cytomegalovirus
Wang, X., Huang, D. Y., Huong, S.-M., & Huang, E.-S. (2005) · Nature Medicine · doi:10.1038/nm1236 · Cited by 268
Self-citationBentz, G. L., Jarquin-Pardo, M., Chan, G., Smith, M. S., Sinzger, C., & Yurochko, A. D. (2006) · Journal of Virology · doi:10.1128/jvi.01016-06 · Cited by 130
Streblow, D. N., Dumortier, J., Moses, A. V., Orloff, S. L., & Nelson, J. A. (2008) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-540-77349-8_22 · Cited by 125
Metadata
- Authors
- Speir, E., Modali, R., Huang, E.-S., Leon, M. B., Shawl, F., Finkel, T., & Epstein, S. E.
- Venue
- Science
- Published
- 1994-07-15
- Volume
- 265
- Issue
- 5170
- Pages
- 391-394
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061404129
- Cited by
- 753
- References
- 1
- FWCI
- 50.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Speir, E., Modali, R., Huang, E.-S., Leon, M. B., Shawl, F., Finkel, T., & Epstein, S. E. (1994). Potential Role of Human Cytomegalovirus and p53 Interaction in Coronary Restenosis. Science. https://doi.org/10.1126/science.8023160
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
