The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
The Story of Human Cytomegalovirus and Cancer: Increasing Evidence and Open Questions
Open accessAbstract
Although human cytomegalovirus (HCMV) is generally not regarded to be an oncogenic virus, HCMV infection has been implicated in malignant diseases from different cancer entities. On the basis of our experimental findings, we developed the concept of "oncomodulation" to better explain the role of HCMV in cancer. Oncomodulation means that HCMV infects tumor cells and increases their malignancy. By this concept, HCMV was proposed to be a therapeutic target in a fraction of cancer patients. However, the clinical relevance of HCMV-induced oncomodulation remains to be clarified. One central question that has to be definitively answered is if HCMV establishes persistent virus replication in tumor cells or not. In our eyes, recent clinical findings from different groups in glioblastoma patients and especially the detection of a correlation between the numbers of HCMV-infected glioblastoma cells and tumor stage (malignancy) strongly increase the evidence that HCMV may exert oncomodulatory effects. Here, we summarize the currently available knowledge about the molecular mechanisms that may contribute to oncomodulation by HCMV as well as the clinical findings that suggest that a fraction of tumors from different entities is indeed infected with HCMV.
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Cites
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Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)
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Cited by
Cytomegalovirus infection enhances the immune response to influenza
Furman, D., Jojic, V., Sharma, S., Shen-Orr, S. S., L. Angel, C. J., Onengut-Gumuscu, S., Kidd, B. A., Maecker, H. T., Concannon, P., Dekker, C. L., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa2293 · Cited by 332
Aiello, A. E., Chiu, Y.-L., & Frasca, D. (2017) · GeroScience · doi:10.1007/s11357-017-9983-9 · Cited by 73
MicroRNA miR-21 Attenuates Human Cytomegalovirus Replication in Neural Cells by Targeting Cdc25a
Fu, Y.-R., Liu, X.-J., Li, X.-J., Shen, Z.-Z., Yang, B., Wu, C.-C., Li, J.-F., Miao, L.-F., Ye, H.-Q., Qiao, G.-H., et al. (2015) · Journal of Virology · doi:10.1128/jvi.01740-14 · Cited by 69
(2015) · Cancer Cell & Microenvironment · doi:10.14800/ccm.678 · Cited by 32
Nogalski, M. T., & Shenk, T. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017734117 · Cited by 25
Metadata
- Authors
- Michaelis, M., Doerr, H. W., & Cinatl, J.
- Venue
- Neoplasia
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 11
- Issue
- 1
- Pages
- 1-9
- ISSN
- 1476-5586 (ISSN-L)
- OpenAlex
- W2130272830
- Cited by
- 293
- References
- 75
- FWCI
- 12.95
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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