The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Regulation of CD8 + T Cell Development by Thymus-Specific Proteasomes
Abstract
Proteasomes are responsible for generating peptides presented by the class I major histocompatibility complex (MHC) molecules of the immune system. Here, we report the identification of a previously unrecognized catalytic subunit called β5t. β5t is expressed exclusively in cortical thymic epithelial cells, which are responsible for the positive selection of developing thymocytes. Although the chymotrypsin-like activity of proteasomes is considered to be important for the production of peptides with high affinities for MHC class I clefts, incorporation of β5t into proteasomes in place of β5 or β5i selectively reduces this activity. We also found that β5t-deficient mice displayed defective development of CD8 + T cells in the thymus. Our results suggest a key role for β5t in generating the MHC class I–restricted CD8 + T cell repertoire during thymic selection.
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Self-citationStructure of 20S proteasome from yeast at 2.4Å resolution
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DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES
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Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
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Selecting and maintaining a diverse T-cell repertoire
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Selecting and maintaining a diverse T-cell repertoire
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Positive selection of lymphocytes
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Cited by
Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome
Finley, D. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.081507.101607 · Cited by 1,764
The proteasome: overview of structure and functions
TANAKA, K. (2009) · Proceedings of the Japan Academy, Series B · doi:10.2183/pjab.85.12 · Cited by 862
Self-citationMolecular mechanisms of proteasome assembly
Murata, S., Yashiroda, H., & Tanaka, K. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2630 · Cited by 546
Self-citationRegulation of proteasome assembly and activity in health and disease
Rousseau, A., & Bertolotti, A. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0040-z · Cited by 510
Hikosaka, Y., Nitta, T., Ohigashi, I., Yano, K., Ishimaru, N., Hayashi, Y., Matsumoto, M., Matsuo, K., Penninger, J. M., Takayanagi, H., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.06.018 · Cited by 433
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Metadata
- Authors
- Murata, S., Sasaki, K., Kishimoto, T., Niwa, S.-I., Hayashi, H., Takahama, Y., & Tanaka, K.
- Venue
- Science
- Published
- 2007-06
- Volume
- 316
- Issue
- 5829
- Pages
- 1349-1353
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2017082201
- Cited by
- 580
- References
- 25
- FWCI
- 10.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Murata, S., Sasaki, K., Kishimoto, T., Niwa, S.-I., Hayashi, H., Takahama, Y., & Tanaka, K. (2007). Regulation of CD8 + T Cell Development by Thymus-Specific Proteasomes. Science. https://doi.org/10.1126/science.1141915
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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