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Cited by 392

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Lymphocyte life-span and memory

Sprent, J, Tough, D.·1994·Science
DOI 10.1126/science.8073282
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Abstract

Differentiation of immature T and B cells in the primary lymphoid organs gives rise to a pool of long-lived lymphocytes that recirculate through the secondary lymphoid tissues. On the basis of their surface markers, T and B cells comprise a mixture of naïve and memory cells with differing life-spans. Immunization (and vaccination) causes naïve lymphocytes to proliferate and differentiate into effector cells and memory cells. Whether the survival of memory cells is innate or requires persistent contact with residual antigen is controversial. Resolving this issue may be crucial for designing optimal vaccines.

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Crossref · 10.1126/science.8073282

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Metadata

Authors
Sprent, J., & Tough, D.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1994-09-02
Volume
265
Issue
5177
Pages
1395-1400
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8073282
OpenAlex
W1978408586
Cited by
392
References
2
FWCI
7.46
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Lymphocyte life-span and memory. https://app.cochat.ai/papers/10.1126/science.8073282
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Sprent, J., & Tough, D. (1994). Lymphocyte life-span and memory. Science. https://doi.org/10.1126/science.8073282

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.