Memory B and T Cells

Vitetta, E S; Berton, M T; Burger, C; Kepron, M; Lee, W T; Yin, X M

doi:10.1146/annurev.iy.09.040191.001205

Cited by 190T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

Memory B and T Cells

Vitetta, E S, Berton, M T, Burger, C, Kepron, M, Lee, W T, Yin, X M·1991·Annual Review of Immunology

DOI 10.1146/annurev.iy.09.040191.001205

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Abstract

Three remarkable and unique features of the immune system are specificity, diversity, and memory. Immunological memory involves both T and B cells and results in a secondary antibody response that is faster, of higher affinity, and results in the secretion of non-IgM isotypes of Ig. In this review we discuss the properties of memory T and B cells, their specific receptors, and the events which occur both in the nucleus and on the cell surface during generation and activation of these cells. Although memory T and B cells use different mechanisms to elaborate memory, there are a number of interesting analogies: lymphokines vs antibodies and affinity maturation of B cell antigen receptors vs upregulation of adhesion molecules on T cells. Finally, we discuss the importance of these cells in health and disease and suggest what impact additional information about these cells might have on the manipulation of the immune response.

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These memory cells mediate a speedy and more effective immune response upon reencounter of the antigen.
“These memory cells mediate a speedy and more effective immune response upon reencounter of the antigen (13,1258).”
From About Sleep's Role in Memory (2013) · cites this paper as [1258]

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Authors: Vitetta, E. S., Berton, M. T., Burger, C., Kepron, M., Lee, W. T., & Yin, X. M.
Affiliations: The University of Texas Southwestern Medical Center (US)
ORCID: Lee, W T
Yin, X M
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 1991-04
Volume: 9
Issue: 1
Pages: 193-217
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.iy.09.040191.001205
OpenAlex: W2025036070
Cited by: 187
References: 0
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 3 · 2012: 3
FWCI: 7.47
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ai021229-05, 5f32ai007959-02, 2p01ai011851-16)
National Institute of Allergy and Infectious Diseases (AI-07959, AI-21229, AI11851)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: memory B cells, memory T cells, immunological memory, secondary antibody response, B cell receptor, T cell receptor, affinity maturation, lymphokines, adhesion molecules, T cell activation, B cell activation
MeSH terms: Animals, Antibody Affinity, Antigens, Differentiation, B-Lymphocytes, Cell Survival, Humans, Immunologic Memory, T-Lymphocytes

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