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Rapid induction of Alzheimer A beta amyloid formation by zinc
Abstract
A beta 1-40, a major component of Alzheimer's disease cerebral amyloid, is present in the cerebrospinal fluid and remains relatively soluble at high concentrations (less than or equal to 3.7 mM). Thus, physiological factors which induce A beta amyloid formation could provide clues to the pathogenesis of the disease. It has been shown that human A beta specifically and saturably binds zinc. Here, concentrations of zinc above 300 nM rapidly destabilized human A beta 1-40 solutions, inducing tinctorial amyloid formation. However, rat A beta 1-40 binds zinc less avidly and is immune to these effects, perhaps explaining the scarcity with which these animals form cerebral A beta amyloid. These data suggest a role for cerebral zinc metabolism in the neuropathogenesis of Alzheimer's disease.
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“For example, it was shown that that metal ions promote Aβ aggregation,16,17 as well as formation of reactive oxygen species (ROS) and lead to oxidative stress.18–20”
From The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity (2013) · cites this paper as [16]
In the citing paper
“Several studies showed that Zn2+ promotes formation of nonfibrillar aggregates,16,29–31 yet conflicting results have been reported for the Cu2+-mediated Aβ aggregation.”
From The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity (2013) · cites this paper as [16]
In the citing paper
“These metal ions have been shown to affect Aβ aggregation, as well as lead to the formation of reactive oxygen species (ROS).12−16”
From Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity (2014) · cites this paper as [12]
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Metadata
- Authors
- Bush, A., Pettingell, W., Multhaup, G., d Paradis, M., Vonsattel, J., Gusella, J., Beyreuther, K., Masters, C., & Tanzi, R.
- Affiliations
- Harvard University (US)
- Heidelberg University (DE)
- Mental Health Research Institute (AU)
- Venue
- Science
- Published
- 1994-09-02
- Volume
- 265
- Issue
- 5177
- Pages
- 1464-1467
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2094808560
- Cited by
- 1,522
- References
- 31
- Citations by year
- 2026: 20 · 2025: 24 · 2024: 28 · 2023: 46 · 2022: 36 · 2021: 52 · 2020: 68 · 2019: 56 · 2018: 58 · 2017: 78 · 2016: 64 · 2015: 60 · 2014: 74 · 2013: 64 · 2012: 80
- FWCI
- 21.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag011899-03, 5r01ns030428-07)
- National Institute on Aging (R01 AG11899-01)
- National Institute of Neurological Disorders and Stroke (R01 NS30428-03)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- Alzheimer's disease, Aβ40, zinc binding, amyloid fibril formation, zinc metabolism, cerebrospinal fluid, neuropathogenesis
- MeSH terms
- Alzheimer Disease, Animals, Brain, Edetic Acid, Humans, Kinetics, Peptide Fragments, Solubility, Zinc, Amyloid beta-Peptides, Mice, Rats
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