Cited by 1,522Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchTrace Elements in Health

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Rapid induction of Alzheimer A beta amyloid formation by zinc

Bush, A., Pettingell, W., Multhaup, G, d Paradis, M, Vonsattel, J., Gusella, J., Beyreuther, K, Masters, C., Tanzi, R.·1994·Science

DOI 10.1126/science.8073293

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Abstract

A beta 1-40, a major component of Alzheimer's disease cerebral amyloid, is present in the cerebrospinal fluid and remains relatively soluble at high concentrations (less than or equal to 3.7 mM). Thus, physiological factors which induce A beta amyloid formation could provide clues to the pathogenesis of the disease. It has been shown that human A beta specifically and saturably binds zinc. Here, concentrations of zinc above 300 nM rapidly destabilized human A beta 1-40 solutions, inducing tinctorial amyloid formation. However, rat A beta 1-40 binds zinc less avidly and is immune to these effects, perhaps explaining the scarcity with which these animals form cerebral A beta amyloid. These data suggest a role for cerebral zinc metabolism in the neuropathogenesis of Alzheimer's disease.

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Authors: Bush, A., Pettingell, W., Multhaup, G., d Paradis, M., Vonsattel, J., Gusella, J., Beyreuther, K., Masters, C., & Tanzi, R.
Affiliations: Harvard University (US)
Heidelberg University (DE)
Mental Health Research Institute (AU)
ORCID: Bush, A.
Multhaup, G
Gusella, J.
Masters, C.
Tanzi, R.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1994-09-02
Volume: 265
Issue: 5177
Pages: 1464-1467
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.8073293
OpenAlex: W2094808560
Cited by: 1,522
References: 31
Citations by year: 2026: 20 · 2025: 24 · 2024: 28 · 2023: 46 · 2022: 36 · 2021: 52 · 2020: 68 · 2019: 56 · 2018: 58 · 2017: 78 · 2016: 64 · 2015: 60 · 2014: 74 · 2013: 64 · 2012: 80
FWCI: 21.76
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ag011899-03, 5r01ns030428-07)
National Institute on Aging (R01 AG11899-01)
National Institute of Neurological Disorders and Stroke (R01 NS30428-03)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: Alzheimer's disease, Aβ40, zinc binding, amyloid fibril formation, zinc metabolism, cerebrospinal fluid, neuropathogenesis
MeSH terms: Alzheimer Disease, Animals, Brain, Edetic Acid, Humans, Kinetics, Peptide Fragments, Solubility, Zinc, Amyloid beta-Peptides, Mice, Rats

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Rapid induction of Alzheimer A beta amyloid formation by zinc

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