The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor
Abstract
The role of the low-affinity neurotrophin receptor (p75 NTR ) in signal transduction is undefined. Nerve growth factor can activate the sphingomyelin cycle, generating the putative-lipid second messenger ceramide. In T9 glioma cells, addition of a cell-permeable ceramide analog mimicked the effects of nerve growth factor on cell growth inhibition and process formation. This signaling pathway appears to be mediated by p75 NTR in T9 cells and NIH 3T3 cells overexpressing p75 NTR . Expression of an epidermal growth factor receptor-p75 NTR chimera in T9 cells imparted to epidermal growth factor the ability to activate the sphingomyelin cycle. These data demonstrate that p75 NTR is capable of signaling independently of the trk neurotrophin receptor (p140 trk ) and that ceramide may be a mediator in neurotrophin biology.
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Cites
The trk Proto-Oncogene Product: a Signal Transducing Receptor for Nerve Growth Factor
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Self-citationGene transfer and molecular cloning of the rat nerve growth factor receptor
Radeke, M. J., Misko, T. P., Hsu, C., Herzenberg, L. A., & Shooter, E. M. (1987) · Nature · doi:10.1038/325593a0 · Cited by 938
Cited by
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195
Grasping objects: the cortical mechanisms of visuomotor transformation
Jeannerod, M., Arbib, M. A., Rizzolatti, G., & Sakata, H. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93921-j · Cited by 1,399
Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair
Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1217 · Cited by 1,284
Neurotrophin Signaling Through the P75 Neurotrophin Receptor
Roux, P. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00016-3 · Cited by 717
Neurotrophic factors and their receptors.
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The Biological Functions and Signaling Mechanisms of the p75 Neurotrophin Receptor
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Metadata
- Authors
- Dobrowsky, R. T., Werner, M. H., Castellino, A. M., Chao, M. V., & Hannun, Y. A.
- Venue
- Science
- Published
- 1994-09-09
- Volume
- 265
- Issue
- 5178
- Pages
- 1596-1599
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1986841583
- Cited by
- 584
- References
- 2
- FWCI
- 19.36
- Type
- journal article
- Language
- en
- Open access
- closed
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