The DOI matches its Crossref record.
Premature p34 cdc2 Activation Required for Apoptosis
Abstract
Activation of the serine-threonine kinase p34 cdc2 at an inappropriate time during the cell cycle leads to cell death that resembles apoptosis. Premature activation of p34 cdc2 was shown to be required for apoptosis induced by a lymphocyte granule protease. The kinase was rapidly activated and tyrosine dephosphorylated at the initiation of apoptosis. DNA fragmentation and nuclear collapse could be prevented by blocking p34 cdc2 activity with excess peptide substrate, or by inactivating p34 cdc2 in a temperature-sensitive mutant. Premature p34 cdc2 activation may be a general mechanism by which cells induced to undergo apoptosis initiate the disruption of the nucleus.
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Citations
Cited by
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Cisplatin: mode of cytotoxic action and molecular basis of resistance
Siddik, Z. H. (2003) · Oncogene · doi:10.1038/sj.onc.1206933 · Cited by 3,335
Meijer, L., Borgne, A., Mulner, O., Chong, J. P. J., Blow, J. J., Inagaki, N., Inagaki, M., Delcros, J., & Moulinoux, J. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.t01-2-00527.x · Cited by 1,352
Brunner, T., Mogil, R. J., LaFace, D., Yoo, N. J., Mahboubi, A., Echeverri, F., Martin, S. J., Force, W. R., Lynch, D. H., Ware, C. F., et al. (1995) · Nature · doi:10.1038/373441a0 · Cited by 1,314
The biochemistry of programmed cell death
Kroemer, G., Petit, P., Zamzami, N., Vayssière, J., & Mignotte, B. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.13.7557017 · Cited by 990
Metadata
- Authors
- Shi, L., Nishioka, W. K., Th'ng, J., Bradbury, E. M., Litchfield, D. W., & Greenberg, A. H.
- Venue
- Science
- Published
- 1994-02-25
- Volume
- 263
- Issue
- 5150
- Pages
- 1143-1145
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1970825176
- Cited by
- 557
- References
- 0
- FWCI
- 31.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Shi, L., Nishioka, W. K., Th'ng, J., Bradbury, E. M., Litchfield, D. W., & Greenberg, A. H. (1994). Premature p34 cdc2 Activation Required for Apoptosis. Science. https://doi.org/10.1126/science.8108732
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
