The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Protein-Protein Interactions Contributing to the Specificity of Intracellular Vesicular Trafficking
Abstract
Intracellular vesicles destined to fuse with the plasma membrane and secrete their contents must have a mechanism for specifically interacting with the appropriate target membrane. Such a mechanism is now suggested by the demonstration of specific interaction between vesicular proteins and plasma membrane proteins. The vesicle-associated membrane proteins (VAMPs) 1 and 2 specifically bind the acceptor membrane proteins syntaxin 1A and 4 but not syntaxin 2 or 3. The binding site is within amino acids 194 to 267 of syntaxin 1A, and the approximate equilibrium dissociation constant is 4.7 × 10 -6 molar. These data suggest a physical basis for the specificity of intracellular vesicular transport.
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Citations
Cites
Predicting coiled coils from protein sequences.
Lupas, A., Van Dyke, M., & Stock, J. (1991) · Science · doi:10.1126/science.252.5009.1162 · Cited by 3,953
Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones
Bennett, M. K., Calakos, N., & Scheller, R. H. (1992) · Science · doi:10.1126/science.1321498 · Cited by 1,263
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Cited by
SNAREs — engines for membrane fusion
Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635
Self-citationMechanisms of intracellular protein transport
Rothman, J. E. (1994) · Nature · doi:10.1038/372055a0 · Cited by 2,265
Membrane Fusion and Exocytosis
Jahn, R., & Südhof, T. C. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.863 · Cited by 1,259
Protein Sorting by Transport Vesicles
Rothman, J. E., & Wieland, F. T. (1996) · Science · doi:10.1126/science.272.5259.227 · Cited by 1,153
Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex
Misura, K. M. S., Scheller, R. H., & Weis, W. I. (2000) · Nature · doi:10.1038/35006120 · Cited by 785
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Metadata
- Authors
- Calakos, N., Bennett, M. K., Peterson, K. E., & Scheller, R. H.
- Venue
- Science
- Published
- 1994-02-25
- Volume
- 263
- Issue
- 5150
- Pages
- 1146-1149
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2009435363
- Cited by
- 399
- References
- 2
- FWCI
- 20.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Calakos, N., Bennett, M. K., Peterson, K. E., & Scheller, R. H. (1994). Protein-Protein Interactions Contributing to the Specificity of Intracellular Vesicular Trafficking. Science. https://doi.org/10.1126/science.8108733
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
