The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Interaction of MHC Class I Molecules with the Transporter Associated with Antigen Processing
Abstract
The transporter associated with antigen processing (TAP) delivers cytosolic peptides into the endoplasmic reticulum (ER) where they bind to nascent class I histocompatibility molecules. Class I-peptide complexes are then displayed at the cell surface for recognition by cytotoxic T lymphocytes. Immunoprecipitation of either TAP or class I molecules revealed an association between the transporter and diverse class I products. TAP bound preferentially to heterodimers of the class I heavy chain and β 2 -microglobulin, and the complex subsequently dissociated in parallel with transport of class I molecules from the ER to the Golgi apparatus. The TAP-class I complexes could also be dissociated in vitro by the addition of class I-binding peptides. The association of class I molecules with TAP likely promotes efficient capture of peptides before their exposure to the lumen of the ER.
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Citations
Cites
Characterization of Peptides Bound to the Class I MHC Molecule HLA-A2.1 by Mass Spectrometry
Hunt, D. F., Henderson, R. A., Shabanowitz, J., Sakaguchi, K., Michel, H., Sevilir, N., Cox, A. L., Appella, E., & Engelhard, V. H. (1992) · Science · doi:10.1126/science.1546328 · Cited by 1,198
Introduction of soluble protein into the class I pathway of antigen processing and presentation
Moore, M. W., Carbone, F. R., & Bevan, M. J. (1988) · Cell · doi:10.1016/s0092-8674(88)91043-4 · Cited by 1,092
The Biochemistry and Cell Biology of Antigen Processing and Presentation
Germain, R. (1993) · Annual Review of Immunology · doi:10.1146/annurev.immunol.11.1.403 · Cited by 1,020
Association of class I major histocompatibility heavy and light chains induced by viral peptides
Townsend, A., Öhlén, C., Bastin, J., Ljunggren, H.-G., Foster, L., & Kärre, K. (1989) · Nature · doi:10.1038/340443a0 · Cited by 985
Empty MHC class I molecules come out in the cold
Ljunggren, H.-G., Stam, N. J., Öhlén, C., Neefjes, J. J., Höglund, P., Heemels, M.-T., Bastin, J., Schumacher, T. N. M., Townsend, A., Kärre, K., et al. (1990) · Nature · doi:10.1038/346476a0 · Cited by 926
Peptides Naturally Presented by MHC Class I Molecules
Rammensee, H. G., Falk, K., & Rötzschke, O. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001241 · Cited by 799
Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters
Trowsdale, J., Hanson, I., Mockridge, I., Beck, S., Townsendt, A., & Kelly, A. (1990) · Nature · doi:10.1038/348741a0 · Cited by 704
Spies, T., Bresnahan, M., Bahrain, S., Arnold, D., Blanck, G., Mellins, E., Pious, D., & DeMars, R. (1990) · Nature · doi:10.1038/348744a0 · Cited by 633
Ozato, K., & Sachs, D. H. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.126.1.317 · Cited by 571
Proteolysis, proteasomes and antigen presentation
Goldberg, A. L., & Rock, K. L. (1992) · Nature · doi:10.1038/357375a0 · Cited by 568
Cited by
Herpes simplex virus turns off the TAP to evade host immunity
Hill, A., Jugovic, P., York, L., Russ, G., Bennink, J., Yewdell, J., Ploegh, H., & Johnson, D. (1995) · Nature · doi:10.1038/375411a0 · Cited by 803
Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation
Junker, F., Gordon, J., & Qureshi, O. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01393 · Cited by 219
CD4 + T Cells: Guardians of the Phagosome
Tubo, N. J., & Jenkins, M. K. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00097-13 · Cited by 105
Rangaraju, S., Raza, S. A., Pennati, A., Deng, Q., Dammer, E. B., Duong, D., Pennington, M. W., Tansey, M. G., Lah, J. J., Betarbet, R., et al. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0906-6 · Cited by 75
Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy
Hattori, T., Maso, L., Araki, K. Y., Koide, A., Hayman, J., Akkapeddi, P., Bang, I., Neel, B. G., & Koide, S. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-1074 · Cited by 72
Metadata
- Authors
- Suh, W.-K., Cohen-Doyle, M. F., Fruh, K., Wang, K., Peterson, P. A., & Williams, D. B.
- Venue
- Science
- Published
- 1994-05-27
- Volume
- 264
- Issue
- 5163
- Pages
- 1322-1326
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024023167
- Cited by
- 295
- References
- 44
- FWCI
- 12.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Suh, W.-K., Cohen-Doyle, M. F., Fruh, K., Wang, K., Peterson, P. A., & Williams, D. B. (1994). Interaction of MHC Class I Molecules with the Transporter Associated with Antigen Processing. Science. https://doi.org/10.1126/science.8191286
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
