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Cited by 219Monoclonal and Polyclonal Antibodies ResearchSystemic Lupus Erythematosus ResearchT-cell and B-cell Immunology

Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation

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Junker, Fabian, Gordon, John, Qureshi, Omar·2020·Frontiers in Immunology
DOI 10.3389/fimmu.2020.01393PMC PMC7350606
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Abstract

The cellular uptake, intracellular processing, and presentation of foreign antigen are crucial processes for eliciting an effective adaptive host response to the majority of pathogens. The effective recognition of antigen by T cells requires that it is first processed and then presented on MHC molecules that are expressed on other cells. A critical step leading to the presentation of antigen is delivering the foreign cargo to an intracellular compartment where the antigen can be processed and loaded onto MHC molecules. Fc-gamma receptors (FcγRs) recognize IgG-coated targets, such as opsonized pathogens or immune complexes (ICs). Cross-linking leads to internalization of the cargo with associated activation of down-stream signaling cascades. FcγRs vary in their affinity for IgG and intracellular trafficking, and therefore have an opportunity to regulate antigen presentation by controlling the shuttling and processing of their cargos. In this way, they critically influence physiological and pathophysiological adaptive immune cell functions. In this review, we will cover the contribution of FcγRs to antigen-presentation with a focus on the intracellular trafficking of IgG-ICs and the pathways that support this function. We will also discuss genetic evidence linking FcγR biology to immune cell activation and autoimmune processes as exemplified by systemic lupus erythematosus (SLE).

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  • FcγRs and CRs-mediated phagocytosis contributed to macrophage proliferation and upregulation of proinflammatory TNF-α, IL-1β, IL-6, and MMP-9 cytokine levels in murine macrophages.

    “Importantly, FcγRs and CRs-mediated phagocytosis also contributed to macrophage proliferation and upregulation of proinflammatory TNF-α, IL-1β, IL-6, and MMP-9 cytokine levels in murine macrophages, respectively [13,14]”

    From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [14]

    The section “Additional Mechanisms of FcγR Enhancement of Antigen-Presentation” reports that IgG immune complexes together with TLR ligands amplify TNF-α, IL-1β, and IL-6 production in human macrophages. It does not establish the claimed macrophage proliferation or MMP-9 increase, nor attribute those outcomes to FcγR- and complement receptor-mediated phagocytosis in murine macrophages. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Junker, F., Gordon, J., & Qureshi, O.
Affiliations
  • F. Hoffmann-La Roche AG (CH)
  • Birmingham Research Park (GB)
Corresponding author
Junker, Fabian
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2020-07-03
Volume
11
Pages
1393-1393
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2020.01393
PMC
PMC7350606
OpenAlex
W3039945792
Cited by
219
References
5
Citations by year
2026: 41 · 2025: 42 · 2024: 42 · 2023: 46 · 2022: 25 · 2021: 20 · 2020: 3
FWCI
3.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
Fc gamma receptor, antigen presentation, antigen uptake, T cell activation, immune complexes, intracellular trafficking, opsonization, adaptive immunity, systemic lupus erythematosus, autoimmune disease, receptor signaling
MeSH terms
Animals, Humans, Lymphocyte Activation, T-Lymphocytes, Receptors, IgG, Antigen Presentation, Adaptive Immunity

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