The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
HTLV-I Tax Protein Stimulation of DNA Binding of bZIP Proteins by Enhancing Dimerization
Abstract
The Tax protein of human T cell leukemia virus type-1 (HTLV-I) transcriptionally activates the HTLV-I promoter. This activation requires binding sites for activating transcription factor (ATF) proteins, a family of cellular proteins that contain basic region-leucine zipper (bZIP) DNA binding domains. Data are presented showing that Tax increases the in vitro DNA binding activity of multiple ATF proteins. Tax also stimulated DNA binding by other bZIP proteins, but did not affect DNA binding proteins that lack a bZIP domain. The increase in DNA binding occurred because Tax promotes dimerization of the bZIP domain in the absence of DNA, and the elevated concentration of the bZIP homodimer then facilitates the DNA binding reaction. These results help explain how Tax activates viral transcription and transforms cells.
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Cites
Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro
Abate, C., Patel, L., Rauscher, F. J., & Curran, T. (1990) · Science · doi:10.1126/science.2118682 · Cited by 1,573
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
Davis, R. L., Cheng, P.-F., Lassar, A. B., & Weintraub, H. (1990) · Cell · doi:10.1016/0092-8674(90)90088-v · Cited by 765
Suzuki, T., Fujisawa, J. I., Toita, M., & Yoshida, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.610 · Cited by 256
Friedman, A. D., & McKnight, S. L. (1990) · Genes & Development · doi:10.1101/gad.4.8.1416 · Cited by 162
Cited by
Metabolism of sulfur amino acids in Saccharomyces cerevisiae.
Thomas, D., & Surdin-Kerjan, Y. (1997) · Microbiology and molecular biology reviews : MMBR · doi:10.1128/.61.4.503-532.1997 · Cited by 678
Merika, M., & Orkin, S. H. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2437 · Cited by 462
Lee, S. S., Weiss, R. S., & Javier, R. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6670 · Cited by 356
Sanchez, H. B., Yieh, L., & Osborne, T. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1161 · Cited by 257
HTLV Tax: A Fascinating Multifunctional Co-Regulator of Viral and Cellular Pathways
Currer, R., Van Duyne, R., Jaworski, E., Guendel, I., Sampey, G., Das, R., Narayanan, A., & Kashanchi, F. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00406 · Cited by 156
Metadata
- Authors
- Wagner, S., & Green, M. R.
- Venue
- Science
- Published
- 1993-10-15
- Volume
- 262
- Issue
- 5132
- Pages
- 395-399
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039871973
- Cited by
- 304
- References
- 4
- FWCI
- 16.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wagner, S., & Green, M. R. (1993). HTLV-I Tax Protein Stimulation of DNA Binding of bZIP Proteins by Enhancing Dimerization. Science. https://doi.org/10.1126/science.8211160
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