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Cooperation by Sterol Regulatory Element-binding Protein and Sp1 in Sterol Regulation of Low Density Lipoprotein Receptor Gene
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Sp1 binds on either side of the SREBP-2 binding site for synergistic LDLR transcriptional activation.
“and Sp1 which binds on either side of the SREBP-2 binding site for synergistic LDLR transcriptional activation30,31.”
From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [30]
The introduction says Sp1 binds LDLR promoter repeats 1 and 3, while repeat 2 binds SREBP; the Results report synergistic promoter activation when Sp1 and SREBP are expressed together. But the binding experiments identify SREBP-1, not the SREBP-2 isoform specified in the claim, so this paper does not establish that isoform-specific interaction. (LLM, conf=0.88)
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Steroidogenic Acute Regulatory Protein
Christenson, L. K., & Strauss, J. F. (2001) · Archives of Medical Research · doi:10.1016/s0188-4409(01)00338-1 · Cited by 146
Athanikar, J. N., Sanchez, H. B., & Osborne, T. F. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5193 · Cited by 88
Self-citationShea-Eaton, W. K., Trinidad, M. J., Lopez, D., Nackley, A., & McLean, M. P. (2001) · Endocrinology · doi:10.1210/endo.142.4.8075 · Cited by 80
Pathways and Molecular Mechanisms Governing LDL Receptor Regulation
Schmidt, H. M., Jarrett, K. E., de Aguiar Vallim, T. Q., & Tarling, E. J. (2025) · Circulation Research · doi:10.1161/circresaha.124.323578 · Cited by 33
Metadata
- Authors
- Sanchez, H. B., Yieh, L., & Osborne, T. F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-01
- Volume
- 270
- Issue
- 3
- Pages
- 1161-1169
- ISSN
- 0021-9258
- Cited by
- 257
- References
- 2
- Language
- en
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