Cited by 257

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Cooperation by Sterol Regulatory Element-binding Protein and Sp1 in Sterol Regulation of Low Density Lipoprotein Receptor Gene

Sanchez, Hugo B., Yieh, Lynn, Osborne, Timothy F.·1995·Journal of Biological Chemistry

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Crossref · 10.1074/jbc.270.3.1161

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  • Sp1 binds on either side of the SREBP-2 binding site for synergistic LDLR transcriptional activation.

    “and Sp1 which binds on either side of the SREBP-2 binding site for synergistic LDLR transcriptional activation30,31.”

    From Pathways and Molecular Mechanisms Governing LDL Receptor Regulation (2025) · cites this paper as [30]

    The introduction says Sp1 binds LDLR promoter repeats 1 and 3, while repeat 2 binds SREBP; the Results report synergistic promoter activation when Sp1 and SREBP are expressed together. But the binding experiments identify SREBP-1, not the SREBP-2 isoform specified in the claim, so this paper does not establish that isoform-specific interaction. (LLM, conf=0.88)

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Metadata

Authors
Sanchez, H. B., Yieh, L., & Osborne, T. F.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1995-01
Volume
270
Issue
3
Pages
1161-1169
ISSN
0021-9258
Cited by
257
References
2
Language
en

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