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Formation of a Molten Globule Intermediate Early in the Kinetic Folding Pathway of Apomyoglobin
Abstract
Hydrogen exchange pulse labeling and stopped-flow circular dichroism were used to establish that the structure of the earliest detectable intermediate formed during refolding of apomyoglobin corresponds closely to that of a previously characterized equilibrium molten globule. This compact, cooperatively folded intermediate was formed in less than 5 milliseconds and contained stable, hydrogen-bonded secondary structure localized in the A, G, and H helices and part of the B helix. The remainder of the B helix folded on a much slower time scale, followed by the C and E helices and the CD loop. The data indicate that a molten globule intermediate was formed on the kinetic folding pathway.
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Cited by
THEORY OF PROTEIN FOLDING: The Energy Landscape Perspective
Onuchic, J. N., Luthey-Schulten, Z., & Wolynes, P. G. (1997) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.48.1.545 · Cited by 2,210
Principles of protein folding — A perspective from simple exact models
Dill, K. A., Bromberg, S., Yue, K., Chan, H. S., Fiebig, K. M., Yee, D. P., & Thomas, P. D. (1995) · Protein Science · doi:10.1002/pro.5560040401 · Cited by 1,525
Gaussian Dynamics of Folded Proteins
Haliloglu, T., Bahar, I., & Erman, B. (1997) · Physical Review Letters · doi:10.1103/physrevlett.79.3090 · Cited by 772
The structural aspects of limited proteolysis of native proteins
Hubbard, S. J. (1998) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(97)00175-1 · Cited by 406
Direct observation of fast protein folding: the initial collapse of apomyoglobin.
Ballew, R. M., Sabelko, J., & Gruebele, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5759 · Cited by 314
Metadata
- Authors
- Jennings, P. A., & Wright, P. E.
- Venue
- Science
- Published
- 1993-11-05
- Volume
- 262
- Issue
- 5135
- Pages
- 892-896
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2074991560
- Cited by
- 728
- References
- 0
- FWCI
- 13.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jennings, P. A., & Wright, P. E. (1993). Formation of a Molten Globule Intermediate Early in the Kinetic Folding Pathway of Apomyoglobin. Science. https://doi.org/10.1126/science.8235610
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
