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Cited by 254

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Rad: a Member of the Ras Family Overexpressed in Muscle of Type II Diabetic Humans

Reynet, Christine, Kahn, C. Ronald·1993·Science
DOI 10.1126/science.8248782
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Abstract

To identify the gene or genes associated with insulin resistance in Type II (non-insulin-dependent) diabetes mellitus, subtraction libraries were prepared from skeletal muscle of normal and diabetic humans and screened with subtracted probes. Only one clone out of 4000 was selectively overexpressed in Type II diabetic muscle as compared to muscle of non-diabetic or Type I diabetic individuals. This clone encoded a new 29-kilodalton member of the Ras-guanosine triphosphatase superfamily and was termed Rad (Ras associated with diabetes). Messenger ribonucleic acid of Rad was expressed primarily in skeletal and cardiac muscle and was increased an average of 8.6-fold in the muscle of Type II diabetics as compared to normal individuals.

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Crossref · 10.1126/science.8248782

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Citations

Cites

Research works printed but not linked: 52

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Cited by

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Metadata

Authors
Reynet, C., & Kahn, C. R.
Affiliations
Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA 02215.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1993-11-26
Volume
262
Issue
5138
Pages
1441-1444
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.8248782
Cited by
254
References
6
Language
en

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