The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression
Abstract
Transforming growth factor beta (TGF-β) is a multifunctional factor that regulates many aspects of cellular functions. TGF-β signals through a heteromeric complex of the type I and type II TGF-β receptors. However, the molecular mechanism of signal transduction by this receptor complex remains unresolved. The type II receptor belongs to a transmembrane receptor serine-threonine kinase family. A new member of this receptor family (R4) was identified and shown to be a functional TGF-β type I receptor on the basis of its ability to restore a TGF-β-induced gene response in mutant cell lines lacking endogenous type I receptor. Both ligand binding and signaling of the R4 protein were dependent on the presence of a functional type II receptor. The type I receptor has an intrinsic serine-threonine kinase activity, which was essential for signal transduction.
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Metadata
- Authors
- Bassing, C. H., Yingling, J. M., Howe, D. J., Wang, T., He, W. W., Gustafson, M. L., Shah, P., Donahoe, P. K., & Wang, X.-F.
- Venue
- Science
- Published
- 1994-01-07
- Volume
- 263
- Issue
- 5143
- Pages
- 87-89
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969390276
- Cited by
- 289
- References
- 16
- FWCI
- 18.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bassing, C. H., Yingling, J. M., Howe, D. J., Wang, T., He, W. W., Gustafson, M. L., Shah, P., Donahoe, P. K., & Wang, X.-F. (1994). A Transforming Growth Factor β Type I Receptor that Signals to Activate Gene Expression. Science. https://doi.org/10.1126/science.8272871
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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