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Phospholipase D: a Downstream Effector of ARF in Granulocytes
Abstract
Activation of the phospholipase D (PLD) pathway is a widespread response when cells are activated by agonists that bind receptors on the cell surface. A 16-kD cytosolic component can reconstitute guanosine triphosphate (GTP)-mediated activation of phospholipase D in HL60 cells depleted of their cytosol by permeabilization. This factor was purified and identified as two small GTP-binding proteins, ARF1 and ARF3. Recombinant ARF1 substituted for purified ARF proteins in the reconstitution assay. These results indicate that phospholipase D is a downstream effector of ARF1 and ARF3. The well-established role of ARF in vesicular traffic would suggest that alterations in lipid content by PLD are an important determinant in vesicular dynamics.
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Citations
Cited by
Martin, T. F. J. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.231 · Cited by 522
Membranes: A meeting point for lipids, proteins and therapies
Escribá, P. V., González‐Ros, J. M., Goñi, F. M., Kinnunen, P. K. J., Vigh, L., Sánchez‐Magraner, L., Fernández, A. M., Busquets, X., Horváth, I., & Barceló‐Coblijn, G. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00281.x · Cited by 454
The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton
Randazzo, P. A., Andrade, J., Miura, K., Brown, M. T., Long, Y.-Q., Stauffer, S., Roller, P., & Cooper, J. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070552297 · Cited by 210
Targeting phospholipase D in cancer, infection and neurodegenerative disorders
Brown, H. A., Thomas, P. G., & Lindsley, C. W. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.252 · Cited by 209
Lambeth, J. D., Kwak, J.-Y., Bowman, E. P., Perry, D., Uhlinger, D. J., & Lopez, I. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.6.2431 · Cited by 104
Metadata
- Authors
- Cockcroft, S., Thomas, G. M. H., Fensome, A., Geny, B., Cunningham, E., Gout, I., Hiles, I., Totty, N. F., Truong, O., & Hsuan, J. J.
- Venue
- Science
- Published
- 1994-01-28
- Volume
- 263
- Issue
- 5146
- Pages
- 523-526
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979945257
- Cited by
- 631
- References
- 0
- FWCI
- 34.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cockcroft, S., Thomas, G. M. H., Fensome, A., Geny, B., Cunningham, E., Gout, I., Hiles, I., Totty, N. F., Truong, O., & Hsuan, J. J. (1994). Phospholipase D: a Downstream Effector of ARF in Granulocytes. Science. https://doi.org/10.1126/science.8290961
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
