The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
G protein-coupled signal transduction pathways for interleukin-8
Abstract
Interleukin-8 (IL-8) is one of the major mediators of the inflammatory response. The pathways by which IL-8 activates inositide-specific phospholipase C (PLC) were investigated by co-expression of different components of the guanosine triphosphate binding protein (G protein) pathway in COS-7 cells. Two distinct IL-8 receptors reconstituted ligand-dependent activation of endogenous PLC when transfected together with the G protein alpha subunits G alpha 14, G alpha 15, or G alpha 16. However, reconstitution was not observed with cells that overexpressed G alpha q or G alpha 11. Furthermore, IL-8 receptors interacted with endogenous pertussis toxin-sensitive G proteins or with the recombinant G protein Gi to release free beta gamma subunits that could then specifically activate the beta 2 isoform of PLC. These findings suggest that IL-8 acts through signal-transducing pathways that are limited to specific heterotrimeric G proteins and effectors. These may provide suitable targets for the development of anti-inflammatory agents.
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Cites
Interleukin-8 as a macrophage-derived mediator of angiogenesis
Koch, A. E., Polverini, P. J., Kunkel, S. L., Harlow, L. A., DiPietro, L. A., Elner, V. M., Elner, S. G., & Strieter, R. M. (1992) · Science · doi:10.1126/science.1281554 · Cited by 2,135
Cited by
Koch, W. J., Hawes, B. E., Inglese, J., Luttrell, L. M., & Lefkowitz, R. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37587-7 · Cited by 421
Chemokines and Their Receptors in the Central Nervous System
Bajetto, A., Bonavia, R., Barbero, S., Florio, T., & Schettini, G. (2001) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0214 · Cited by 416
Mutations in a C. elegans Gqα Gene Disrupt Movement, Egg Laying, and Viability
Brundage, L., Avery, L., Katz, A., Kim, U.-J., Mendel, J. E., Sternberg, P. W., & Simon, M. I. (1996) · Neuron · doi:10.1016/s0896-6273(00)80123-3 · Cited by 195
Self-citationMechanisms of Abruption-Induced Premature Rupture of the Fetal Membranes
Lockwood, C. J., Toti, P., Arcuri, F., Paidas, M., Buchwalder, L., Krikun, G., & Schatz, F. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61230-8 · Cited by 97
Metadata
- Authors
- Wu, D., LaRosa, G., & Simon, M.
- Venue
- Science
- Published
- 1993-07-02
- Volume
- 261
- Issue
- 5117
- Pages
- 101-103
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005400238
- Cited by
- 382
- References
- 1
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- closed
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