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Cited by 1,813

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Structure of the actin-myosin complex and its implications for muscle contraction

Rayment, I, Holden, H., Whittaker, M, Yohn, C., Lorenz, M, Holmes, K., Milligan, R.·1993·Science

Abstract

Muscle contraction consists of a cyclical interaction between myosin and actin driven by the concomitant hydrolysis of adenosine triphosphate (ATP). A model for the rigor complex of F actin and the myosin head was obtained by combining the molecular structures of the individual proteins with the low-resolution electron density maps of the complex derived by cryo-electron microscopy and image analysis. The spatial relation between the ATP binding pocket on myosin and the major contact area on actin suggests a working hypothesis for the crossbridge cycle that is consistent with previous independent structural and biochemical studies.

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Crossref · 10.1126/science.8316858

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Metadata

Authors
Rayment, I., Holden, H., Whittaker, M., Yohn, C., Lorenz, M., Holmes, K., & Milligan, R.
Venue
Science
Published
1993-07-02
Volume
261
Issue
5117
Pages
58-65
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2044629144
Cited by
1,813
References
2
FWCI
94.28
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Structure of the actin-myosin complex and its implications for muscle contraction. https://app.cochat.ai/papers/10.1126/science.8316858
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Rayment, I., Holden, H., Whittaker, M., Yohn, C., Lorenz, M., Holmes, K., & Milligan, R. (1993). Structure of the actin-myosin complex and its implications for muscle contraction. Science. https://doi.org/10.1126/science.8316858

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.