Microtubules and microtubule-associated proteins
Abstract
Microtubule research is becoming increasingly diverse, reflecting the many isoforms and modifications of tubulin and the many proteins with which microtubules interact. Recent advances are particularly visible in four areas: microtubule motor proteins (their structures, stepping modes, and forces); microtubule nucleation (the roles of centrosomes and gamma-tubulin); tubulin folding (mediated by cytoplasmic chaperones); and the expanding list of microtubule-associated proteins, knowledge of their phosphorylation states, and information on their effects on microtubule dynamics.
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Microtubule-associated proteins bind to stabilize and promote assembly of microtubules.
“Microtubule-associated proteins (MAPs) bind to stabilize and promote assembly of microtubules1, 2.”
From Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau (2017) · cites this paper as [1]
Cites
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Tau stabilizes microtubules by binding at the interface between tubulin heterodimers
Kadavath, H., Hofele, R. V., Biernat, J., Kumar, S., Tepper, K., Urlaub, H., Mandelkow, E., & Zweckstetter, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504081112 · Cited by 524 · see citing works
Self-citationAlzheimer's disease and type 2 diabetes: a critical assessment of the shared pathological traits
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- Authors
- Mandelkow, E., & Mandelkow, E.-M.
- Affiliations
- Max Planck Unit for Structural Molecular Biology (DE)
- ORCID
- Mandelkow, Eva-Maria
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 1995-01
- Volume
- 7
- Issue
- 1
- Pages
- 72-81
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2015171213
- Cited by
- 458
- References
- 5
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 11 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 16 · 2017: 22 · 2016: 19 · 2015: 13 · 2014: 13 · 2013: 10 · 2012: 13
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Desy Publications Database (Deutsches Elektronen-Synchrotron DESY) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Keywords
- microtubules, tubulin isoforms, tubulin modification, microtubule motor proteins, kinesin, dynein, microtubule nucleation, centrosome, gamma-tubulin, tubulin folding, molecular chaperones, microtubule-associated proteins, protein phosphorylation, microtubule dynamics
- MeSH terms
- Animals, Cell Movement, Microtubule-Associated Proteins, Microtubules, Sequence Homology, Nucleic Acid, Tubulin, tau Proteins, Centrosome, Molecular Chaperones
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