The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Induction of Apoptosis by the Low-Affinity NGF Receptor
Abstract
Nerve growth factor (NGF) binding to cellular receptors is required for the survival of some neural cells. In contrast to TrkA, the high-affinity NGF receptor that transduces NGF signals for survival and differentiation, the function of the low-affinity NGF receptor, p75 NGFR , remains uncertain. Expression of p75 NGFR induced neural cell death constitutively when p75 NGFR was unbound; binding by NGF or monoclonal antibody, however, inhibited cell death induced by p75 NGFR . Thus, expression of p75 NGFR may explain the dependence of some neural cells on NGF for survival. These findings also suggest that p75 NGFR has some functional similarities to other members of a superfamily of receptors that include tumor necrosis factor receptors, Fas (Apo-1), and CD40.
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Cites
Gene transfer and molecular cloning of the rat nerve growth factor receptor
Radeke, M. J., Misko, T. P., Hsu, C., Herzenberg, L. A., & Shooter, E. M. (1987) · Nature · doi:10.1038/325593a0 · Cited by 938
Cited by
Neurotrophin signal transduction in the nervous system
Kaplan, D. R., & Miller, F. D. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00092-1 · Cited by 1,944
Grasping objects: the cortical mechanisms of visuomotor transformation
Jeannerod, M., Arbib, M. A., Rizzolatti, G., & Sakata, H. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93921-j · Cited by 1,399
The yin and yang of neurotrophin action
Lu, B., Pang, P. T., & Woo, N. H. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1726 · Cited by 1,356
Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair
Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1217 · Cited by 1,284
Boldin, M. P., Varfolomeev, E. E., Pancer, Z., Mett, I. L., Camonis, J. H., & Wallach, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.14.7795 · Cited by 993
Metadata
- Authors
- Rabizadeh, S., Oh, J., Zhong, L.-T., Yang, J., Bitler, C. M., Butcher, L. L., & Bredesen, D. E.
- Venue
- Science
- Published
- 1993-07-16
- Volume
- 261
- Issue
- 5119
- Pages
- 345-348
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990073151
- Cited by
- 782
- References
- 1
- FWCI
- 18.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
