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Induction of Apoptosis by the Low-Affinity NGF Receptor
Abstract
Nerve growth factor (NGF) binding to cellular receptors is required for the survival of some neural cells. In contrast to TrkA, the high-affinity NGF receptor that transduces NGF signals for survival and differentiation, the function of the low-affinity NGF receptor, p75 NGFR , remains uncertain. Expression of p75 NGFR induced neural cell death constitutively when p75 NGFR was unbound; binding by NGF or monoclonal antibody, however, inhibited cell death induced by p75 NGFR . Thus, expression of p75 NGFR may explain the dependence of some neural cells on NGF for survival. These findings also suggest that p75 NGFR has some functional similarities to other members of a superfamily of receptors that include tumor necrosis factor receptors, Fas (Apo-1), and CD40.
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Metadata
- Authors
- Rabizadeh, S., Oh, J., Zhong, L.-T., Yang, J., Bitler, C. M., Butcher, L. L., & Bredesen, D. E.
- Venue
- Science
- Published
- 1993-07-16
- Volume
- 261
- Issue
- 5119
- Pages
- 345-348
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1990073151
- Cited by
- 782
- References
- 1
- FWCI
- 18.24
- Type
- journal article
- Language
- en
- Open access
- closed
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