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The Caenorhabditis elegans unc-17 Gene: a Putative Vesicular Acetylcholine Transporter
Abstract
Mutations in the unc-17 gene of the nematode Caenorhabditis elegans produce deficits in neuromuscular function. This gene was cloned and complementary DNAs were sequenced. On the basis of sequence similarity to mammalian vesicular transporters of biogenic amines and of localization to synaptic vesicles of cholinergic neurons in C. elegans, unc-17 likely encodes the vesicular transporter of acetylcholine. Mutations that eliminated all unc-17 gene function were lethal, suggesting that the acetylcholine transporter is essential. Molecular analysis of unc-17 mutations will allow the correlation of specific parts of the gene (and the protein) with observed functional defects. The mutants will also be useful for the isolation of extragenic suppressors, which could identify genes encoding proteins that interact with UNC-17.
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Cites
The pharynx of Caenorhabditis elegans
Albertson, D. G., & Thompson, J. N. (1976) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1976.0085 · Cited by 649
Cited by
Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,547
Alzheimer's disease: Targeting the Cholinergic System
H. Ferreira-Vieira, T., M. Guimaraes, I., R. Silva, F., & M. Ribeiro, F. (2016) · Current Neuropharmacology · doi:10.2174/1570159x13666150716165726 · Cited by 1,551
Neurobiology of the Caenorhabditis elegans Genome
Bargmann, C. I. (1998) · Science · doi:10.1126/science.282.5396.2028 · Cited by 929
Active Currents Regulate Sensitivity and Dynamic Range in C. elegans Neurons
Goodman, M. B., Hall, D. H., Avery, L., & Lockery, S. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)81014-4 · Cited by 370
A cellular and regulatory map of the cholinergic nervous system of C. elegans
Pereira, L., Kratsios, P., Serrano-Saiz, E., Sheftel, H., Mayo, A. E., Hall, D. H., White, J. G., LeBoeuf, B., Garcia, L. R., Alon, U., et al. (2015) · eLife · doi:10.7554/elife.12432 · Cited by 365
Metadata
- Authors
- Alfonso, A., Grundahl, K., Duerr, J. S., Han, H.-P., & Rand, J. B.
- Venue
- Science
- Published
- 1993-07-30
- Volume
- 261
- Issue
- 5121
- Pages
- 617-619
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2086170256
- Cited by
- 376
- References
- 1
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Alfonso, A., Grundahl, K., Duerr, J. S., Han, H.-P., & Rand, J. B. (1993). The Caenorhabditis elegans unc-17 Gene: a Putative Vesicular Acetylcholine Transporter. Science. https://doi.org/10.1126/science.8342028
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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