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Rat Annexin V Crystal Structure: Ca 2+ -Induced Conformational Changes
Abstract
Annexins are a family of calcium- and phospholipid-binding proteins implicated in mediating membrane-related processes such as secretion, signal transduction, and ion channel activity. The crystal structure of rat annexin V was solved to 1.9 angstrom resolution by multiple isomorphous replacement. Unlike previously solved annexin V structures, all four domains bound calcium in this structure. Calcium binding in the third domain induced a large relocation of the calcium-binding loop regions, exposing the single tryptophan residue to the solvent. These alterations in annexin V suggest a role for domain 3 in calcium-triggered interaction with phospholipid membranes.
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Citations
Cited by
Annexins: From Structure to Function
Gerke, V., & Moss, S. E. (2002) · Physiological Reviews · doi:10.1152/physrev.00030.2001 · Cited by 2,029
Structural Mechanisms for Domain Movements in Proteins
Gerstein, M., Lesk, A. M., & Chothia, C. (1994) · Biochemistry · doi:10.1021/bi00188a001 · Cited by 744
Smith, A. L., & Nicolaou, K. C. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm9600398 · Cited by 377
Annexin II tetramer: structure and function
Waisman, D. M. (1995) · Molecular and Cellular Biochemistry · doi:10.1007/bf01076592 · Cited by 273
Metadata
- Authors
- Concha, N. O., Head, J. F., Kaetzel, M. A., Dedman, J. R., & Seaton, B. A.
- Venue
- Science
- Published
- 1993-09-03
- Volume
- 261
- Issue
- 5126
- Pages
- 1321-1324
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2004152842
- Cited by
- 192
- References
- 0
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Rat Annexin V Crystal Structure: Ca 2+ -Induced Conformational Changes. https://app.cochat.ai/papers/10.1126/science.8362244
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- Concha, N. O., Head, J. F., Kaetzel, M. A., Dedman, J. R., & Seaton, B. A. (1993). Rat Annexin V Crystal Structure: Ca 2+ -Induced Conformational Changes. Science. https://doi.org/10.1126/science.8362244
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