Cited by 1,218Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurogenesis and neuroplasticity mechanisms

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Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

Frey, U., Huang, Y.-Y., Kandel, E. R.·1993·Science

DOI 10.1126/science.8389057

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Abstract

Hippocampal long-term potentiation (LTP) is thought to serve as an elementary mechanism for the establishment of certain forms of explicit memory in the mammalian brain. As is the case with behavioral memory, LTP in the CA1 region has stages: a short-term early potentiation lasting 1 to 3 hours, which is independent of protein synthesis, precedes a later, longer lasting stage (L-LTP), which requires protein synthesis. Inhibitors of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) blocked L-LTP, and analogs of cAMP induced a potentiation that blocked naturally induced L-LTP. The action of the cAMP analog was blocked by inhibitors of protein synthesis. Thus, activation of PKA may be a component of the mechanism that generates L-LTP.

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Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1
Sunahara, R. K., Guan, H., O’Dowd, B. F., Seeman, P. M., Laurier, L. G., Ng, G., George, S. R., Torchia, J., Tol, H. H. M. V., & Niznik, H. B. (1991) · Nature · doi:10.1038/350614a0 · Cited by 1,166
An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation
Malenka, R. C., Kauer, J. A., Perkel, D. J., Mauk, M. D., Kelly, P. T., Nicoll, R. A., & Waxham, M. N. (1989) · Nature · doi:10.1038/340554a0 · Cited by 1,025
Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro
Frey, U., Krug, M., Reymann, K. G., & Matthies, H. (1988) · Brain Research · doi:10.1016/0006-8993(88)90008-x · Cited by 806
A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia
Montarolo, P. G., Goelet, P., Castellucci, V. F., Morgan, J., Kandel, E. R., & Schacher, S. (1986) · Science · doi:10.1126/science.3775383 · Cited by 769
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors
O'Dell, T., Kandel, E., & Grant, S. (1991) · Nature · doi:10.1038/353558a0 · Cited by 536
Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats
Krug, M., Lössner, B., & Ott, T. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90005-4 · Cited by 509
Enhancement of the Glutamate Response by cAMP-Dependent Protein Kinase in Hippocampal Neurons
Greengard, P., Jen, J. C., Nairn, A. C., & Stevens, C. F. (1991) · Science · doi:10.1126/science.1716001 · Cited by 497
Regulation of Kainate Receptors by cAMP-Dependent Protein Kinase and Phosphatases
Wang, L., Salter, M. W., & MacDonald, J. F. (1991) · Science · doi:10.1126/science.1653455 · Cited by 394

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Mamiya, T., Noda, Y., Nishi, M., Takeshima, H., & Nabeshima, T. (1999) · Neuroreport · doi:10.1097/00001756-199904260-00003 · Cited by 44
Acute administration of a permeant analog of cAMP and a phosphodiesterase inhibitor improve long-term habituation in the crab Chasmagnathus
Romano, A. G., Delorenzi, A., Pedreira, M. E., Tomsic, D., & Maldonado, H. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00179-9 · Cited by 44
5-HT4 Receptors
Bockaert, J., Ansanay, H., Waeber, C., Sebben, M., Fagni, L., & Dumuis, A. (1994) · CNS Drugs · doi:10.2165/00023210-199401010-00002 · Cited by 44
Synaptic Transmission and Hippocampal Long-Term Potentiation in Olfactory Cyclic Nucleotide-Gated Channel Type 1 Null Mouse
Parent, A., Schrader, K. A., Munger, S. D., Reed, R. R., Linden, D. J., & Ronnett, G. V. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.6.3295 · Cited by 44
Protein kinase Mζ is essential for the induction and maintenance of dopamine-induced long-term potentiation in apical CA1 dendritesPreprint
Navakkode, S., Sajikumar, S., Sacktor, T. C., & Frey, J. U. (2010) · Learning & Memory · doi:10.1101/lm.1991910 · Cited by 46
Properties and mechanisms of olfactory learning and memory
Tong, M. T., Peace, S. T., & Cleland, T. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00238 · Cited by 42
Remembering to Forget: A Dual Role for Sleep Oscillations in Memory Consolidation and Forgetting
Langille, J. J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00071 · Cited by 50
Sequestration of serum response factor in the hippocampus impairs long‐term spatial memory
Dash, P. K., Orsi, S. A., & Moore, A. N. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.03016.x · Cited by 43
The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus
Bouron, A., & REUTER, H. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00352-8 · Cited by 44
Dopamine D1/D5 receptor activation fails to initiate an activity-independent late-phase LTP in rat hippocampus
Mockett, B. G., Brooks, W. M., Tate, W. P., & Abraham, W. C. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.039 · Cited by 43
Correlation of phenotype with genotype in inherited retinal degeneration
Daiger, S. P., Sullivan, L. S., & Rodriguez, J. A. (1995) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00039212 · Cited by 43
Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding
Du, H., Deng, W., Aimone, J. B., Ge, M., Parylak, S., Walch, K., Zhang, W., Cook, J. R., Song, H., Wang, L., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606951113 · Cited by 42
Taurine-induced synaptic potentiation and the late phase of long-term potentiation are related mechanistically
Olmo, N. D., Handler, A., Álvarez, L., Bustamante, J., del Rı́o, R. M., & Solís, J. M. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(02)00310-6 · Cited by 42
Activation of metabotropic glutamate receptors enhances synaptic transmission at the Drosophila neuromuscular junction
Zhang, D., Kuromi, H., & Kidokoro, Y. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(98)00232-9 · Cited by 42
Age-related changes in theta frequency stimulation-induced long-term potentiation
Watabe, A. M., & O’Dell, T. J. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00082-9 · Cited by 42
Protein kinase subtypes involved in injury-induced nociception
Malmberg, A. B. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)29005-5 · Cited by 42
Imaging of cAMP‐dependent protein kinase activity in living neural cells using a novel fluorescent substrate
Higashi, H., Sato, K., Ohtake, A., Omori, A., Yoshida, S., & Kudo, Y. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00970-8 · Cited by 42
Distinct prefrontal molecular mechanisms for information storage lasting seconds versus minutesPreprint
Runyan, J. D., & Dash, P. K. (2005) · Learning & Memory · doi:10.1101/lm.92405 · Cited by 42
Antagonism of group III metabotropic glutamate receptors results in impairment of LTD but not LTP in the hippocampal CA1 region, and prevents long‐term spatial memory
Altinbilek, B., & Manahan‐Vaughan, D. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05742.x · Cited by 41
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Kyrke‐Smith, M., & Williams, J. M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00369 · Cited by 43
Sub-chronic rolipram treatment leads to a persistent improvement in long-term object memory in rats
Rutten, K., Prickaerts, J., Schänzle, G., Rosenbrock, H., & Blokland, A. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.04.016 · Cited by 41
A critical role of CREB in the impairment of late-phase LTP by adult onset hypothyroidism.
Alzoubi, K., & Alkadhi, K. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2006.07.019 · Cited by 37
PKA Has a Critical Role in Synaptic Delivery of GluR1- and GluR4-Containing AMPARs During Initial Stages of Acquisition of In Vitro Classical Conditioning
Zheng, Z., & Keifer, J. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91282.2008 · Cited by 42
The Timing of Learning before Night-Time Sleep Differentially Affects Declarative and Procedural Long-Term Memory Consolidation in Adolescents
Holz, J., Piosczyk, H., Landmann, N., Feige, B., Spiegelhalder, K., Riemann, D. W., Nissen, C., & Voderholzer, U. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040963 · Cited by 43

Authors: Frey, U., Huang, Y.-Y., & Kandel, E. R.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Kandel, E. R.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1993-06-11
Volume: 260
Issue: 5114
Pages: 1661-1664
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.8389057
OpenAlex: W2051473177
Cited by: 1,218
References: 26
Citations by year: 2026: 6 · 2025: 13 · 2024: 24 · 2023: 10 · 2022: 14 · 2021: 31 · 2020: 20 · 2019: 28 · 2018: 29 · 2017: 29 · 2016: 24 · 2015: 40 · 2014: 37 · 2013: 43 · 2012: 47
FWCI: 19.01
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01gm032099-14)
National Institute of General Medical Sciences (GM 32099)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: long-term potentiation, CA1 pyramidal neurons, cyclic AMP, protein kinase A, protein synthesis, memory formation, cAMP analogs, PKA inhibitors
MeSH terms: Action Potentials, Cyclic AMP, Animals, Hippocampus, Male, Memory, Neurons, Protein Kinases, Time Factors, Second Messenger Systems, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Rats, In Vitro Techniques

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Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

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