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Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

Frey, U., Huang, Y.-Y., Kandel, E. R.·1993·Science

DOI 10.1126/science.8389057

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Abstract

Hippocampal long-term potentiation (LTP) is thought to serve as an elementary mechanism for the establishment of certain forms of explicit memory in the mammalian brain. As is the case with behavioral memory, LTP in the CA1 region has stages: a short-term early potentiation lasting 1 to 3 hours, which is independent of protein synthesis, precedes a later, longer lasting stage (L-LTP), which requires protein synthesis. Inhibitors of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) blocked L-LTP, and analogs of cAMP induced a potentiation that blocked naturally induced L-LTP. The action of the cAMP analog was blocked by inhibitors of protein synthesis. Thus, activation of PKA may be a component of the mechanism that generates L-LTP.

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“…is generated by multiple trains of high-frequency stimulation, can last hours or even days, and is sensitive to inhibitors of transcription and translation (Frey et al., 1993; Nguyen et al., 1994). cAMP has been shown to play a role in both D-LTP and L-LTP (Frey et al., 1993; Nguyen et al., 1994).”
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“…neurotransmission within the CA1 influences late phase LTP (L-LTP), a phenomenon that requires protein synthesis and is thought to be a molecular mechanism underlying mnemonic consolidation in CA1 synapses (Frey et al., 1993; Huang et al., 2013; Huang and Kandel, 1995; L€uscher and Malenka, 2012).”
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Authors: Frey, U., Huang, Y.-Y., & Kandel, E. R.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Kandel, E. R.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1993-06-11
Volume: 260
Issue: 5114
Pages: 1661-1664
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.8389057
OpenAlex: W2051473177
Cited by: 1,218
References: 26
Citations by year: 2026: 6 · 2025: 13 · 2024: 24 · 2023: 10 · 2022: 14 · 2021: 31 · 2020: 20 · 2019: 28 · 2018: 29 · 2017: 29 · 2016: 24 · 2015: 40 · 2014: 37 · 2013: 43 · 2012: 47
FWCI: 19.01
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01gm032099-14)
National Institute of General Medical Sciences (GM 32099)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: long-term potentiation, CA1 pyramidal neurons, cyclic AMP, protein kinase A, protein synthesis, memory formation, cAMP analogs, PKA inhibitors
MeSH terms: Action Potentials, Cyclic AMP, Animals, Hippocampus, Male, Memory, Neurons, Protein Kinases, Time Factors, Second Messenger Systems, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Rats, In Vitro Techniques

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Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

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