Cited by 52Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchMemory Processes and Influences

Memory reconsolidation and its maintenance depend on L-voltage-dependent calcium channels and CaMKII functions regulating protein turnover in the hippocampus

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Da Silva, Weber Cláudio, Cardoso, Gabriela, Bonini, Juliana Sartori, Benetti, Fernando, Izquierdo, Ivan·2013·Proceedings of the National Academy of Sciences

Abstract

Immediate postretrieval bilateral blockade of long-acting voltage-dependent calcium channels (L-VDCCs), but not of glutamatergic NMDA receptors, in the dorsal CA1 region of the hippocampus hinders retention of long-term spatial memory in the Morris water maze. Immediate postretrieval bilateral inhibition of calcium/calmodulin-dependent protein kinase (CaMK) II in dorsal CA1 does not affect retention of this task 24 h later but does hinder it 5 d later. These two distinct amnesic effects are abolished if protein degradation by proteasomes is inhibited concomitantly. These results indicate that spatial memory reconsolidation depends on the functionality of L-VDCC in dorsal CA1, that maintenance of subsequent reconsolidated memory trace depends on CaMKII, and these results also suggest that the role played by both L-VDCC and CaMKII is to promote the retrieval-dependent, synaptically localized enhancement of protein synthesis necessary to counteract a retrieval-dependent, synaptic-localized enhancement of protein degradation, which has been described as underlying the characteristic labilization of the memory trace triggered by retrieval. Thus, conceivably, L-VDCC and CaMKII would enhance activity-dependent localized protein renewal, which may account for the improvement of the long-term efficiency of the synapses responsible for the maintenance of reactivated long-term spatial memory.

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Crossref · 10.1073/pnas.1302356110

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Authors
Da Silva, W. C., Cardoso, G., Bonini, J. S., Benetti, F., & Izquierdo, I.
Affiliations
  • Centro de Memória, Instituto do Cérebro, Pontifícia Universidade Católica do Rio Grande do Sul, RS90610-000, Porto Alegre, Brazil;
  • Instituto do Cérebro (BR)
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
Venue
Proceedings of the National Academy of Sciences
Published
2013-04
Volume
110
Issue
16
Pages
6566-6570
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2054146070
Cited by
52
References
61
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 9 · 2014: 7 · 2013: 2
FWCI
4.57
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
memory reconsolidation, CaMKII, hippocampal CA1, spatial memory, proteasome inhibition, protein degradation, protein synthesis, NMDA receptor
MeSH terms
Analysis of Variance, Animals, Hippocampus, Male, Nerve Tissue Proteins, Time Factors, Calcium Channels, Rats, Wistar, Long-Term Potentiation, Maze Learning, Rats, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Memory, Long-Term

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