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Selection of Bacterial Virulence Genes That Are Specifically Induced in Host Tissues
Abstract
A genetic system was devised that positively selects for bacterial genes that are specifically induced when bacteria infect their host. With the pathogen Salmonella typhimurium , the genes identified by this selection show a marked induction in bacteria recovered from mouse spleen. Mutations in all ivi (in vivo-induced) genes that were tested conferred a defect in virulence. This genetic system was designed to be of general use in a wide variety of bacterial-host systems and has several applications in both vaccine and antimicrobial drug development.
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Citations
Cited by
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans
Mitchell, T. G., & Perfect, J. R. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.4.515 · Cited by 1,213
Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence
Smith, I. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.3.463-496.2003 · Cited by 1,154
Eriksson, S., Lucchini, S., Thompson, A., Rhen, M., & Hinton, J. C. D. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03313.x · Cited by 846
Pathogenicity Islands in BacterialPathogenesis
Schmidt, H., & Hensel, M. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.1.14-56.2004 · Cited by 776
Engineering bacteria for diagnostic and therapeutic applications
Riglar, D. T., & Silver, P. A. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.172 · Cited by 460
Metadata
- Authors
- Mahan, M. J., Slauch, J. M., & Mekalanos, J. J.
- Venue
- Science
- Published
- 1993-01-29
- Volume
- 259
- Issue
- 5095
- Pages
- 686-688
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2085972597
- Cited by
- 660
- References
- 0
- FWCI
- 18.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Selection of Bacterial Virulence Genes That Are Specifically Induced in Host Tissues. https://app.cochat.ai/papers/10.1126/science.8430319
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- Mahan, M. J., Slauch, J. M., & Mekalanos, J. J. (1993). Selection of Bacterial Virulence Genes That Are Specifically Induced in Host Tissues. Science. https://doi.org/10.1126/science.8430319
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
