The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Higher Level Organization of Individual Gene Transcription and RNA Splicing
Abstract
Visualization of fibronectin and neurotensin messenger RNAs within mammalian interphase nuclei was achieved by fluorescence hybridization with genomic, complementary DNA, and intron-specific probes. Unspliced transcripts accumulated in one or two sites per nucleus. Fibronectin RNA frequently accumulated in elongated tracks that overlapped and extended well beyond the site of transcription. Splicing appears to occur directly within this RNA track, as evidenced by an unambiguous spatial separation of intron-containing and spliced transcripts. Excised introns for neurotensin RNA appear free to diffuse. The transcription and processing site of the fibronectin gene localized to the nuclear interior and was associated with larger transcript domains in over 88 percent of the cells. These results support a view of nuclear function closely integrated with structure.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Visualization of nucleolar genes
Miller, O. L., & Beatty, B. R. (1969) · Science · doi:10.1126/science.164.3882.955 · Cited by 876
Cited by
Macromolecular Domains within the Cell Nucleus
Spector, D. L. (1993) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.09.110193.001405 · Cited by 601
Sharp, P. (1994) · Cell · doi:10.1016/0092-8674(94)90130-9 · Cited by 567
Functional association between promoter structure and transcript alternative splicing
Cramer, P., Pesce, C. G., Baralle, F. E., & Kornblihtt, A. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11456 · Cited by 344
Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport.
Fortes, P., Beloso, A., & Ortín, J. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06310.x · Cited by 278
Subcellular compartmentalization of adeno-associated virus type 2 assembly
Wistuba, A., Kern, A., Weger, S., Grimm, D., & Kleinschmidt, J. A. (1997) · Journal of Virology · doi:10.1128/jvi.71.2.1341-1352.1997 · Cited by 219
Metadata
- Authors
- Xing, Y., Johnson, C. V., Dobner, P. R., & Lawrence, J. B.
- Venue
- Science
- Published
- 1993-02-26
- Volume
- 259
- Issue
- 5099
- Pages
- 1326-1330
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2094733358
- Cited by
- 407
- References
- 1
- FWCI
- 22.61
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Higher Level Organization of Individual Gene Transcription and RNA Splicing. https://app.cochat.ai/papers/10.1126/science.8446901
- The paper
- Xing, Y., Johnson, C. V., Dobner, P. R., & Lawrence, J. B. (1993). Higher Level Organization of Individual Gene Transcription and RNA Splicing. Science. https://doi.org/10.1126/science.8446901
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
