The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Functional association between promoter structure and transcript alternative splicing
Open accessAbstract
It has been assumed that constitutive and regulated splicing of RNA polymerase II transcripts depends exclusively on signals present in the RNA molecule. Here we show that changes in promoter structure strongly affect splice site selection. We investigated the splicing of the ED I exon, which encodes a facultative type III repeat of fibronectin, whose inclusion is regulated during development and in proliferative processes. We used an alternative splicing assay combined with promoter swapping to demonstrate that the extent of ED I splicing is dependent on the promoter structure from which the transcript originated and that this regulation is independent of the promoter strength. Thus, these results provide the first evidence for coupling between alternative splicing and promoter-specific transcription, which agrees with recent cytological and biochemical evidence of coordination between splicing and transcription.
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Cites
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The C-terminal domain of RNA polymerase II couples mRNA processing to transcription
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The dynamics of a pre-mRNA splicing factor in living cells
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Regulation of Alternative Splicing in Vivo by Overexpression of Antagonistic Splicing Factors
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Higher Level Organization of Individual Gene Transcription and RNA Splicing
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Cited by
Integrating mRNA Processing with Transcription
Proudfoot, N. J., Furger, A., & Dye, M. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00617-7 · Cited by 1,082
Coupling mRNA processing with transcription in time and space
Bentley, D. L. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3662 · Cited by 828
A Slow RNA Polymerase II Affects Alternative Splicing In Vivo
de la Mata, M., Alonso, C. R., Kadener, S., Fededa, J. P., Blaustein, M., Pelisch, F., Cramer, P., Bentley, D., & Kornblihtt, A. R. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.001 · Cited by 683
Self-citationRegulation of Alternative Splicing Through Coupling with Transcription and Chromatin Structure
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Self-citationDynamic integration of splicing within gene regulatory pathways
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Metadata
- Authors
- Cramer, P., Pesce, C. G., Baralle, F. E., & Kornblihtt, A. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-10-14
- Volume
- 94
- Issue
- 21
- Pages
- 11456-11460
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2060148395
- Cited by
- 344
- References
- 25
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Cramer, P., Pesce, C. G., Baralle, F. E., & Kornblihtt, A. R. (1997). Functional association between promoter structure and transcript alternative splicing. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.21.11456
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
