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Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans
Abstract
Supporting cells in the vestibular sensory epithelia from the ears of mature guinea pigs and adult humans proliferate in vitro after treatments with aminoglycoside antibiotics that cause sensory hair cells to die. After 4 weeks in culture, the epithelia contained new cells with some characteristics of immature hair cells. These findings are in contrast to expectations based on previous studies, which had suggested that hair cell loss is irreversible in mammals. The loss of hair cells is responsible for hearing and balance deficits that affect millions of people.
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Citations
Cited by
p27Kip1 links cell proliferation to morphogenesis in the developing organ of Corti
Chen, P., & Segil, N. (1999) · Development · doi:10.1242/dev.126.8.1581 · Cited by 555
Complementary roles of BDNF and NT-3 in vestibular and auditory development
Ernfors, P., Van De Water, T., Loring, J., & Jaenisch, R. (1995) · Neuron · doi:10.1016/0896-6273(95)90263-5 · Cited by 462
Differential Distribution of Stem Cells in the Auditory and Vestibular Organs of the Inner Ear
Oshima, K., Grimm, C. M., Corrales, C. E., Senn, P., Martinez Monedero, R., Géléoc, G. S. G., Edge, A., Holt, J. R., & Heller, S. (2007) · Journal of the Association for Research in Otolaryngology · doi:10.1007/s10162-006-0058-3 · Cited by 349
Implantable bioelectronic interfaces for lost nerve functions
Heiduschka, P., & Thanos, S. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00013-6 · Cited by 126
Metadata
- Authors
- Warchol, M., Lambert, P., Goldstein, B., Forge, A., & Corwin, J.
- Venue
- Science
- Published
- 1993-03-12
- Volume
- 259
- Issue
- 5101
- Pages
- 1619-1622
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995048201
- Cited by
- 510
- References
- 0
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. https://app.cochat.ai/papers/10.1126/science.8456285
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- Warchol, M., Lambert, P., Goldstein, B., Forge, A., & Corwin, J. (1993). Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. Science. https://doi.org/10.1126/science.8456285
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
