The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Complementary roles of BDNF and NT-3 in vestibular and auditory development
Open accessAbstract
The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene. BDNF was the major survival factor for vestibular ganglion neurons, and NT-3, for spiral ganglion neurons. Lack of BDNF and NT-3 did not affect ingrowth of nerve fibers into the vestibular epithelium, but BDNF mutants failed to maintain afferent and efferent innervation. In the cochlea, BDNF mutants lost type 2 spiral neurons, causing an absence of outer hair cell innervation. NT-3 mutants showed a paucity of afferents and lost 87% of spiral neurons, presumably corresponding to type 1 neurons, which innervate inner hair cells. Double mutants had an additive loss, lacking all vestibular and spiral neurons. These results show that BDNF and NT-3 are crucial for inner ear development and, although largely coexpressed, have distinct and nonoverlapping roles in the vestibular and auditory systems.
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Metadata
- Authors
- Ernfors, P., Van De Water, T., Loring, J., & Jaenisch, R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 14
- Issue
- 6
- Pages
- 1153-1164
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2013558874
- Cited by
- 462
- References
- 42
- FWCI
- 23.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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